Immunologic Crosstalk of Endoplasmic Reticulum Stress Signaling in Bladder Cancer.

Autor:	Wan S; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.; Gansu Province Clinical Research Center for Urology, Lanzhou, 730000, PR China., Li KP; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.; Gansu Province Clinical Research Center for Urology, Lanzhou, 730000, PR China., Wang CY; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.; Gansu Province Clinical Research Center for Urology, Lanzhou730000, PR China., Yang JW; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China., Chen SY; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.; Gansu Province Clinical Research Center for Urology, Lanzhou, 730000, PR China., Wang HB; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.; Gansu Province Clinical Research Center for Urology, Lanzhou, 730000, PR China., Li XR; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.; Gansu Province Clinical Research Center for Urology, Lanzhou, 730000, PR China., Yang L; Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.; Gansu Province Clinical Research Center for Urology, Lanzhou, 730000, PR China.
Jazyk:	angličtina
Zdroj:	Current cancer drug targets [Curr Cancer Drug Targets] 2024; Vol. 24 (7), pp. 701-719.
DOI:	10.2174/0115680096272663231121100515
Abstrakt:	Bladder cancer (BC) is a common malignant tumor of the urinary system. While current approaches involving adjuvant chemotherapy, radiotherapy, and immunotherapy have shown significant progress in BC treatment, challenges, such as recurrence and drug resistance, persist, especially in the case of muscle-invasive bladder cancer (MIBC). It is mainly due to the lack of pre-existing immune response cells in the tumor immune microenvironment. Micro-environmental changes (such as hypoxia and under-nutrition) can cause the aggregation of unfolded and misfolded proteins in the lumen, which induces endoplasmic reticulum (ER) stress. ER stress and its downstream signaling pathways are closely related to immunogenicity and tumor drug resistance. ER stress plays a pivotal role in a spectrum of processes within immune cells and the progression of BC cells, encompassing cell proliferation, autophagy, apoptosis, and resistance to therapies. Recent studies have increasingly recognized the potential of natural compounds to exhibit anti-BC properties through ER stress induction. Still, the efficacy of these natural compounds remains less than that of immune checkpoint inhibitors (ICIs). Currently, the ER stress-mediated immunogenic cell death (ICD) pathway is more encouraging, which can enhance ICI responses by mediating immune stemness. This article provides an overview of the recent developments in understanding how ER stress influences tumor immunity and its implications for BC. Targeting this pathway may soon emerge as a compelling therapeutic strategy for BC. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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