Online carbohydrate 3D structure validation with the Privateer web app.

Autor: Dialpuri JS; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., Bagdonas H; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., Schofield LC; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., Pham PT; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., Holland L; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., Bond PS; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., Sánchez Rodríguez F; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., McNicholas SJ; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom., Agirre J; York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 3BG, United Kingdom.
Jazyk: angličtina
Zdroj: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Feb 01; Vol. 80 (Pt 2), pp. 30-35. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1107/S2053230X24000359
Abstrakt: Owing to the difficulties associated with working with carbohydrates, validating glycan 3D structures prior to deposition into the Protein Data Bank has become a staple of the structure-solution pipeline. The Privateer software provides integrative methods for the validation, analysis, refinement and graphical representation of 3D atomic structures of glycans, both as ligands and as protein modifiers. While Privateer is free software, it requires users to install any of the structural biology software suites that support it or to build it from source code. Here, the Privateer web app is presented, which is always up to date and available to be used online (https://privateer.york.ac.uk) without installation. This self-updating tool, which runs locally on the user's machine, will allow structural biologists to simply and quickly analyse carbohydrate ligands and protein glycosylation from a web browser whilst retaining all confidential information on their devices.
(open access.)
Databáze: MEDLINE
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