Lithium management of periodic mood fluctuations in behavioural frontotemporal dementia: a case report.

Autor:	Llorca-Bofí V; Department of Medicine, University of Barcelona School of Medicine, Barcelona, Spain.; Department of Psychiatry, Hospital Universitari Santa María, Lleida, Spain., Batalla I; Department of Psychiatry, Hospital Universitari Santa María, Lleida, Spain.; Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.; Medicine Department, Universitat de Lleida (UdL), Lleida, Spain., Ruiz-Julián M; Cognitive Disorders Unit, Hospital Universitari Santa Maria, Lleida, Spain., Adrados-Pérez M; Department of Psychiatry, Hospital Universitari Santa María, Lleida, Spain., Buil-Reiné E; Department of Psychiatry, Hospital Universitari Santa María, Lleida, Spain., Piñol-Ripoll G; Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.; Medicine Department, Universitat de Lleida (UdL), Lleida, Spain.; Cognitive Disorders Unit, Hospital Universitari Santa Maria, Lleida, Spain., Gallart-Palau X; Biomedical Research Institute of Lleida Dr. Pifarré Foundation (IRB Lleida), Neuroscience Area, +Pec Proteomics Research Group (+PPRG), University Hospital Arnau de Vilanova (HUAV), Lleida, Spain.; Psychology Department, University of Lleida (UdL), Lleida, Spain.; Faculty of Health Sciences, Valencian International University, Valencia, Spain., Torrent A; Department of Psychiatry, Hospital Universitari Santa María, Lleida, Spain.; Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2024 Jan 08; Vol. 14, pp. 1325145. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2023).
DOI:	10.3389/fpsyt.2023.1325145
Abstrakt:	The behavioural variant of Frontotemporal Dementia (bvFTD) is a neurodegenerative condition characterized by behavioural and cognitive symptoms. Mood disturbances, including manic-like episodes, can occur in bvFTD, posing diagnostic and therapeutic challenges. This case report presents a 62-year-old male with bvFTD exhibiting weekly mood fluctuations alternating between manic and depressive-like states. While initial treatment with quetiapine and trazodone showed partial improvement, the periodicity of mood fluctuations persisted. Subsequently, lithium was introduced, resulting in a notable reduction in symptom severity for both manic and depressive episodes. This report highlights the potential use of lithium as a mood stabilizer in bvFTD patients with periodic mood fluctuations, refractory to standard treatments. Further research is needed to elucidate the mechanisms underlying lithium's efficacy in bvFTD and to establish treatment guidelines. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Llorca-Bofí, Batalla, Ruiz-Julián, Adrados-Pérez, Buil-Reiné, Piñol-Ripoll, Gallart-Palau and Torrent.)
Databáze:	MEDLINE
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