Post-extubation Assessment of Laryngeal Symptoms and Severity (PALSS) in the Intensive Care Unit: Protocol of a Prospective Cohort Study.

Autor:	Pandian V; School of Nursing, Johns Hopkins University.; Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University., Cherukuri SPS; Department of Medicine, MedStar Union Memorial Hospital., Koneru M; Department of Pediatrics, Brooklyn Hospital Center., Karne V; Department of Pathology and Laboratory Medicine, University of Southern California., Tajrishi FZ; Emory University., Aloori S; Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University., Kota P; Neurocardiology research program of excellence, University of California, Los Angeles., Dinglas V; Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University., Colantuoni E; Bloomberg School of Public Health, Johns Hopkins University., Akst L; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University., Hillel AT; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University., Needham DM; School of Nursing, Johns Hopkins University.; Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University.; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University., Brodsky MB; Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University.; Speech-Language Pathology, Head and Neck Institute, Cleveland Clinic.; Department of Physical Medicine and Rehabilitation, Johns Hopkins University.
Jazyk:	angličtina
Zdroj:	ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses [ORL Head Neck Nurs] 2024; Vol. 42 (1), pp. 8-21.
Abstrakt:	Aims: The Post-extubation Assessment of Laryngeal Symptoms and Severity (PALSS) study systematically evaluates patient symptoms related to endotracheal intubation with mechanical ventilation, assesses laryngeal injury and voice function after extubation, and develops a screening tool to identify patients with clinically important, post-extubation laryngeal injury. Design: Single-center, prospective observational cohort study conducted in 6 intensive care units (ICU). Methods: Patients ≥18 years old who are orally intubated and mechanically ventilated in an ICU and meet eligibility criteria will undergo flexible laryngoscopy, with a sample size goal of 300 completed laryngoscopies. Primary outcome measures include signs and symptoms of laryngeal injury, including voice symptoms and alterations in swallowing, measured using the Laryngeal Hypersensitivity Questionnaire-Acute and Voice Symptom Scale questionnaires respectively. Data will be collected within 72 hours post-extubation and at 7-day follow-up or hospital discharge (whichever occurs first). Data will be analyzed using descriptive statistics, regression models, and predictive modeling using machine learning. Discussion: The findings of this study will describe the clinical signs and symptoms of laryngeal injury post-extubation. Conclusion: The PALSS study will provide insights for future studies that explore laryngeal injuries using flexible laryngoscopy after endotracheal intubation. Implications for Patient Care: Identifying signs and symptoms of laryngeal injury after endotracheal intubation will facilitate the development of a screening tool that will assist in early identification of post-extubation laryngeal injury, and aid in decreasing short- and long-term complications of endotracheal intubation. Reporting Method: SPIRIT. Patient or Public Contribution: Patients were study participants; and family members provided informed consent when the patient lacked decision-making capacity. Competing Interests: This study is funded by the National Institute of Nursing Research of the National Institute of Health, Bethesda, United States.Conflict of Interest Statement No conflict of interest
Databáze:	MEDLINE
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