Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO).

Autor: Ng DHL; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore., Chia TRT; National Centre of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore., Young BE; National Centre of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Sadarangani S; National Centre of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Puah SH; Department of Respiratory & Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore., Low JGH; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, Singapore, Singapore., Yan GZ; Division of Infectious Diseases, National University Hospital, Singapore, Singapore., Mo Y; Division of Infectious Diseases, National University Hospital, Singapore, Singapore., Ngiam NJ; Division of Infectious Diseases, National University Hospital, Singapore, Singapore., Wang SSY; National Centre of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore., Loo YT; National Centre of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore., Ong FEJQ; National Centre of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore., Li AY; Division of Respiratory & Critical Care Medicine, Department of Medicine, National University Hospital, Singapore, Singapore., Ho S; Department of Respiratory & Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore., Ng L; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore., Tambyah PA; Division of Infectious Diseases, National University Hospital, Singapore, Singapore.; Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yeo TW; National Centre of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore. yeotsinwen@ntu.edu.sg.; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore. yeotsinwen@ntu.edu.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. yeotsinwen@ntu.edu.sg.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2024 Jan 23; Vol. 24 (1), pp. 123. Date of Electronic Publication: 2024 Jan 23.
DOI: 10.1186/s12879-023-08795-8
Abstrakt: Background: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic platforms to accurately identify the causes of moderate-to-severe community-acquired pneumonia in adults and understand the factors influencing disease caused by individual pathogens. The study is currently underway in Singapore and has plans for expansion into the broader region.
Methods: RESPIRO is being conducted at three major tertiary hospitals in Singapore. Adults hospitalised with acute community-acquired pneumonia or lower respiratory tract infections, based on established clinical, laboratory and radiological criteria, will be recruited. Over the course of the illness, clinical data and biological samples will be collected longitudinally and stored in a biorepository for future analysis.
Discussion: The RESPIRO study is designed to be hypothesis generating, complementary to and easily integrated with other research projects and clinical trials. The detailed clinical database and biorepository will yield insights into the epidemiology and outcomes of community-acquired lower respiratory tract infections in Singapore and the surrounding region and offers the opportunity to deeply characterise the microbiology and immunopathology of community-acquired pneumonia.
(© 2024. The Author(s).)
Databáze: MEDLINE
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