Effect of serum vitamin D levels on the severity of acute pancreatitis: A prospective study.

Autor: Ocal S; Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Turkey., Cerci K; Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey., Buldukoglu OC; Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Turkey. Electronic address: cbuldukoglu@hotmail.com., Atar GE; Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Turkey., Harmandar FA; Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Turkey., Cekin AH; Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Turkey.
Jazyk: angličtina
Zdroj: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2024 Mar; Vol. 24 (2), pp. 206-210. Date of Electronic Publication: 2024 Jan 11.
DOI: 10.1016/j.pan.2024.01.004
Abstrakt: Acute pancreatitis (AP) is a serious and complex disorder with varying disease course and severity. Early and prompt interventions are crucial in management of AP. Vitamin D, being a prominent actor in calcium metabolism, also takes part in immunity and thus in immune-system related disorders, ranging from infections to cancer. In this study, the role of vitamin D status of a patient on the severity of AP was investigated. This study was conducted between June 2021 to August 2022 with a total of 315 patients. Blood samples were obtained upon admission. A 25-(OH)D3 level less than 10 ng/ml was defined as vitamin D deficiency. 10-19 ng/ml was defined as vitamin D insufficiency whereas 20 ng/ml or above was considered to be sufficient. Scoring systems (Ranson score, CTSI, BISAP, Revised Atlanta Classification (RAC) were applied. Serum 25-(OH)D3 levels of patients with AP were found to be negatively correlated with severity of the disease according to RAC (p < 0.001). In concordance to this finding, both Ranson score and BISAP were found to be statistically significantly related to 25-(OH)D3 levels. Both scoring systems revealed higher scores in patients with insufficient or deficient levels of 25-(OH)D3. Serum 25-(OH)D3 levels were not found to be related to intensive care unit admission or mortality. This study revealed that serum 25-(OH)D3 level is related to the severity of AP. In the future, interventional studies with vitamin D therapy in otherwise serum 25-(OH)D3 deficient AP patients might reveal a new potential therapeutic agent in this mechanically complex, burdensome disorder.
Competing Interests: Declaration of competing interest Authors declare no conflict of interest for this article.
(Copyright © 2024 IAP and EPC. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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