Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program.

Autor: Oh J; Department of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA., Buckley JP; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Epidemiology, University of North Carolina at Chapel Hill (UNC-Chapel Hill), Chapel Hill, North Carolina, USA., Li X; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Gachigi KK; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Kannan K; Wadsworth Center, Division of Environmental Health Sciences, New York State Department of Health, Albany, New York, USA.; Department of Environmental Health Sciences, University at Albany, State University of New York, Albany, New York, USA., Lyu W; Department of Pediatrics, New York University (NYU) Grossman School of Medicine, New York, New York, USA.; Department of Environmental Medicine, NYU Grossman School of Medicine, New York, New York, USA., Ames JL; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Barrett ES; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA.; Environmental and Occupational Health Sciences Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, USA., Bastain TM; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA., Breton CV; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA., Buss C; Department of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Pediatrics, UC-Irvine School of Medicine, Orange, California, USA., Croen LA; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Dunlop AL; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA., Ferrara A; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Ghassabian A; Department of Pediatrics, New York University (NYU) Grossman School of Medicine, New York, New York, USA.; Department of Environmental Medicine, NYU Grossman School of Medicine, New York, New York, USA.; Department of Population Health, NYU Grossman School of Medicine, New York, New York, USA., Herbstman JB; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA., Hernandez-Castro I; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA., Hertz-Picciotto I; Department of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA.; Medical Investigations of Neurodevelopmental Disorders Institute, UC-Davis, Sacramento, California, USA., Kahn LG; Department of Pediatrics, New York University (NYU) Grossman School of Medicine, New York, New York, USA.; Department of Population Health, NYU Grossman School of Medicine, New York, New York, USA., Karagas MR; Department of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire, USA., Kuiper JR; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., McEvoy CT; Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA., Meeker JD; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA., Morello-Frosch R; Department of Environmental Science, Policy and Management and School of Public Health, UC-Berkeley, Berkeley, California, USA., Padula AM; Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA., Romano ME; Department of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire, USA., Sathyanarayana S; Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, Washington, USA., Schantz S; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA., Schmidt RJ; Department of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA.; Medical Investigations of Neurodevelopmental Disorders Institute, UC-Davis, Sacramento, California, USA., Simhan H; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Starling AP; Department of Epidemiology, Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, North Carolina, USA.; Center for Lifecourse Epidemiology of Adiposity and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Tylavsky FA; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Volk HE; Department of Mental Health, Johns Hopkins University, Baltimore, Maryland, USA., Woodruff TJ; Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA., Zhu Y; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Bennett DH; Department of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA.
Jazyk: angličtina
Zdroj: Environmental health perspectives [Environ Health Perspect] 2024 Jan; Vol. 132 (1), pp. 17004. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1289/EHP13182
Abstrakt: Background: Widespread exposure to organophosphate ester (OPE) flame retardants with potential reproductive toxicity raises concern regarding the impacts of gestational exposure on birth outcomes. Previous studies of prenatal OPE exposure and birth outcomes had limited sample sizes, with inconclusive results.
Objectives: We conducted a collaborative analysis of associations between gestational OPE exposures and adverse birth outcomes and tested whether associations were modified by sex.
Methods: We included 6,646 pregnant participants from 16 cohorts in the Environmental influences on Child Health Outcomes (ECHO) Program. Nine OPE biomarkers were quantified in maternal urine samples collected primarily during the second and third trimester and modeled as log 2 -transformed continuous, categorized (high/low/nondetect), or dichotomous (detect/nondetect) variables depending on detection frequency. We used covariate-adjusted linear, logistic, and multinomial regression with generalized estimating equations, accounting for cohort-level clustering, to estimate associations of OPE biomarkers with gestational length and birth weight outcomes. Secondarily, we assessed effect modification by sex.
Results: Three OPE biomarkers [diphenyl phosphate (DPHP), a composite of dibutyl phosphate and di-isobutyl phosphate (DBUP/DIBP), and bis(1,3-dichloro-2-propyl) phosphate] were detected in > 85 % of participants. In adjusted models, DBUP/DIBP [odds ratio (OR) per doubling = 1.07 ; 95% confidence interval (CI): 1.02, 1.12] and bis(butoxyethyl) phosphate (OR for high vs. nondetect = 1.25 ; 95% CI: 1.06, 1.46), but not other OPE biomarkers, were associated with higher odds of preterm birth. We observed effect modification by sex for associations of DPHP and high bis(2-chloroethyl) phosphate with completed gestational weeks and odds of preterm birth, with adverse associations among females. In addition, newborns of mothers with detectable bis(1-chloro-2-propyl) phosphate, bis(2-methylphenyl) phosphate, and dipropyl phosphate had higher birth weight-for-gestational-age z -scores ( β for detect vs. nondetect = 0.04 - 0.07 ); other chemicals showed null associations.
Discussion: In the largest study to date, we find gestational exposures to several OPEs are associated with earlier timing of birth, especially among female neonates, or with greater fetal growth. https://doi.org/10.1289/EHP13182.
Databáze: MEDLINE
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