Population clustering of structural brain aging and its association with brain development.

Autor:	Duan H; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, China., Shi R; School of Data Science, Fudan University, Shanghai, China., Kang J; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, China., Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany., Bokde ALW; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Büchel C; University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Desrivières S; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Flor H; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany., Grigis A; NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France., Garavan H; Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA., Gowland PA; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom., Heinz A; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Brühl R; Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany., Martinot JL; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories and Psychiatry', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.; Psychiatry Department, EPS Barthélémy Durand, Etampes; France., Martinot MP; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories and Psychiatry', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.; AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France., Artiges E; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories and Psychiatry', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.; Psychiatry Department, EPS Barthélémy Durand, Etampes; France., Nees F; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein Kiel University, Kiel, Germany., Papadopoulos Orfanos D; NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France., Poustka L; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075, Göttingen, Germany., Hohmann S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany., Holz N; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany., Fröhner JH; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Smolka MN; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Vaidya N; Department of Psychiatry and Neurosciences, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Walter H; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Whelan R; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland., Schumann G; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.; Department of Psychiatry and Neurosciences, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Centre for Population Neuroscience and Stratified Medicine (PONS Centre), ISTBI, Fudan University, Shanghai, China.; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany., Lin X; School of Data Science, Fudan University, Shanghai, China.; Huashan Institute of Medicine, Huashan Hospital affiliated to Fudan University, Shanghai, China., Feng J; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, China.; School of Data Science, Fudan University, Shanghai, China.; MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.; Zhangjiang Fudan International Innovation Center, Shanghai, China.; Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 26. Date of Electronic Publication: 2024 Jun 26.
DOI:	10.1101/2024.01.09.24301030
Abstrakt:	Structural brain aging has demonstrated strong inter-individual heterogeneity and mirroring patterns with brain development. However, due to the lack of large-scale longitudinal neuroimaging studies, most of the existing research focused on the cross-sectional changes of brain aging. In this investigation, we present a data-driven approach that incorporate both cross-sectional changes and longitudinal trajectories of structural brain aging and identified two brain aging patterns among 37,013 healthy participants from UK Biobank. Participants with accelerated brain aging also demonstrated accelerated biological aging, cognitive decline and increased genetic susceptibilities to major neuropsychiatric disorders. Further, by integrating longitudinal neuroimaging studies from a multi-center adolescent cohort, we validated the "last in, first out" mirroring hypothesis and identified brain regions with manifested mirroring patterns between brain aging and brain development. Genomic analyses revealed risk loci and genes contributing to accelerated brain aging and delayed brain development, providing molecular basis for elucidating the biological mechanisms underlying brain aging and related disorders. Competing Interests: Dr Banaschewski served in an advisory or consultancy role for eye level, Infectopharm, Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Roche, and Takeda. He received conference support or speaker’s fee by Janssen, Medice and Takeda. He received royalities from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press; the present work is unrelated to these relationships. Dr Poustka served in an advisory or consultancy role for Roche and Viforpharm and received speaker’s fee by Shire. She received royalties from Hogrefe, Kohlhammer and Schattauer. The present work is unrelated to the above grants and relationships. The other authors report no biomedical financial interests or potential conflicts of interest.
Databáze:	MEDLINE
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