Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood.

Autor:	Bulgarelli C; Centre for Brain and Cognitive Development, Birkbeck, University of London, UK.; Department of Medical Physics and Biomedical Engineering, University College London, UK., Blasi A; Department of Medical Physics and Biomedical Engineering, University College London, UK., McCann S; Department of Women and Children's Health, King's College London, UK.; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia., Milosavljevic B; Department of Psychology, University of Cambridge, UK.; School of Biological and Experimental Psychology, Queen Mary University of London, UK., Ghillia G; Department of Women and Children's Health, King's College London, UK., Mbye E; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia., Touray E; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia., Fadera T; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia., Acolatse L; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia.; Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Ireland., Moore SE; Department of Women and Children's Health, King's College London, UK.; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia., Lloyd-Fox S; Department of Psychology, University of Cambridge, UK., Elwell CE; Department of Medical Physics and Biomedical Engineering, University College London, UK., Eggebrecht AT; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 03. Date of Electronic Publication: 2024 Jan 03.
DOI:	10.1101/2024.01.02.573930
Abstrakt:	Functional brain network organization, measured by functional connectivity (FC), reflects key neurodevelopmental processes for healthy development. Early exposure to adversity, e.g. undernutrition, affects neurodevelopment, observable via disrupted FC, and leads to poorer outcomes from preschool age onward. We assessed longitudinally the impact of early growth trajectories on developmental FC in a rural Gambian population from age 5 to 24 months. To investigate how these early trajectories relate to later childhood outcomes, we assessed cognitive flexibility at 3-5 years. We observed that early physical growth before the fifth month of life drove optimal developmental trajectories of FC that in turn predicted cognitive flexibility at pre-school age. In contrast to previously studied developmental populations, this Gambian sample exhibited long-range interhemispheric FC that decreased with age. Our results highlight the measurable effects that poor growth in early infancy has on brain development and the subsequent impact on pre-school age cognitive development, underscoring the need for early life interventions throughout global settings of adversity. Competing Interests: Competing interests: Chiara Bulgarelli is a research consultant for Gowerlabs Ltd., the company that produces the NTS optical topography system used in this work.
Databáze:	MEDLINE
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