Intracranial recordings reveal high-frequency activity in the human temporal-parietal cortex supporting non-literal language processing.

Autor:	Soni S; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada., Overton J; Department of Neuroscience and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Kam JWY; Department of Psychology, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Pexman P; Department of Psychology, University of Calgary, Calgary, AB, Canada., Prabhu A; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States., Garza N; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States., Saez I; Department of Neuroscience, Neurosurgery and Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Girgis F; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Jan 08; Vol. 17, pp. 1304031. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2023).
DOI:	10.3389/fnins.2023.1304031
Abstrakt:	Objective: Non-literal expressions such as sarcasm, metaphor and simile refer to words and sentences that convey meanings or intentions that are different and more abstract than literal expressions. Neuroimaging studies have shown activations in a variety of frontal, parietal and temporal brain regions implicated in non-literal language processing. However, neurophysiological correlates of these brain areas underlying non-literal processing remain underexplored. Methods: To address this, we investigated patterns of intracranial EEG activity during non-literal processing by leveraging a unique patient population. Seven neurosurgical patients with invasive electrophysiological monitoring of superficial brain activity were recruited. Intracranial neural responses were recorded over the temporal-parietal junction (TPJ) and its surrounding areas while patients performed a language task. Participants listened to vignettes that ended with non-literal or literal statements and were then asked related questions to which they responded verbally. Results: We found differential neurophysiological activity during the processing of non-literal statements as compared to literal statements, especially in low-Gamma (30-70 Hz) and delta (1-4 Hz) bands. In addition, we found that neural responses related to non-literal processing in the high-gamma band (>70 Hz) were significantly more prominent at TPJ electrodes as compared to non-TPJ (i.e., control) electrodes in most subjects. Moreover, in half of patients, high-gamma activity related to non-literal processing was accompanied by delta-band modulation. Conclusion: These results suggest that both low- and high-frequency electrophysiological activities in the temporal-parietal junction play a crucial role during non-literal language processing in the human brain. The current investigation, utilizing better spatial and temporal resolution of human intracranial electrocorticography, provides a unique opportunity to gain insights into the localized brain dynamics of the TPJ during the processing of non-literal language expressions. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Soni, Overton, Kam, Pexman, Prabhu, Garza, Saez and Girgis.)
Databáze:	MEDLINE
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