Association between Helicobacter pylori infection and incident risk of dementia: The AMI cohort.

Autor: Hernández-Ruiz V; INSERM, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Bordeaux, France., Roubaud-Baudron C; Pôle de Gérontologie Clinique, CHU Bordeaux, Bordeaux, France.; INSERM, UMR U1312 - BRIC, University of Bordeaux, Bordeaux, France., Von Campe H; INSERM, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Bordeaux, France., Retuerto N; INSERM, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Bordeaux, France., Mégraud F; INSERM, UMR U1312 - BRIC, University of Bordeaux, Bordeaux, France., Helmer C; INSERM, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Bordeaux, France., Amieva H; INSERM, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Bordeaux, France., Pérès K; INSERM, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Bordeaux, France.
Jazyk: angličtina
Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2024 Apr; Vol. 72 (4), pp. 1191-1198. Date of Electronic Publication: 2024 Jan 23.
DOI: 10.1111/jgs.18748
Abstrakt: Background: Chronic infectious diseases are increasingly being considered as potential contributors to dementia risk. Among those infections, Helicobacter pylori, the main cause of chronic gastritis worldwide, has been suggested. As the prevalence of H. pylori infection has decreased, the main objective of this work was to reconsider the association between H. pylori infection and the risk of incident dementia, including Alzheimer's disease.
Methods: Prospective cohort of 689 older (≥65 years) agricultural workers from Southwest France. Descriptive and comparative analyses were performed according to H. pylori status determined by serology at baseline. The risk of incident dementia according to H. pylori status over a 7-year follow-up was explored by survival analyses: Kaplan-Meier curve and Cox proportional hazards models.
Results: Two-hundred (29.0%) participants were H. pylori-positive at baseline. Compared to H. pylori-negative participants, they showed worse cognitive performances at baseline. Eighty-five incident dementia cases were diagnosed during the follow-up period. After adjustment for age, sex, education, apolipoprotein ε4, and several cardiovascular risk factors, H. pylori remained associated with an increased risk of dementia (HR 1.70, 95% CI, 1.05-2.74). The risk was stronger for Alzheimer's disease (HR 2.85, 95% CI, 1.58-5.12).
Conclusions: Despite an observed decrease in H. pylori infection prevalence, this study provides evidence for the association between H. pylori infection and dementia. These results should encourage further research on the mechanisms underlying the contribution of infectious diseases to pathological brain aging, especially the influence of gut inflammation on the brain.
(© 2024 The American Geriatrics Society.)
Databáze: MEDLINE
Externí odkaz: