Customizable Three-Dimensional Printed Earring Tap for Treating Affections Caused by Aesthetic Perforations.

Autor: Pinho LAG; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil., Lima AL; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil., Chen Y; Laboratory for Drug Delivery & Translational Medicine, School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China., Sa-Barreto LL; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil., Marreto RN; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Federal University of Goias, Goiania 74605-170, GO, Brazil., Gelfuso GM; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil., Gratieri T; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil., Cunha-Filho M; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2024 Jan 05; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 05.
DOI: 10.3390/pharmaceutics16010077
Abstrakt: This work aimed to develop a three-dimensional (3D) wearable drug-loaded earring tap to treat affections caused by aesthetic perforations. The initial phase involved a combination of polymers to prepare filaments for fused deposition modeling (FDM) 3D printing using a centroid mixture design. Optimized filament compositions were used in the second phase to produce 3D printed earring taps containing the anti-inflammatory naringenin. Next, samples were assessed via physicochemical assays followed by in vitro skin permeation studies with porcine ear skin. Two filament compositions were selected for the study's second phase: one to accelerate drug release and another with slow drug dissolution. Both filaments demonstrated chemical compatibility and amorphous behavior. The use of the polymer blend to enhance printability has been confirmed by rheological analysis. The 3D devices facilitated naringenin skin penetration, improving drug recovery from the skin's most superficial layer (3D device A) or inner layers (3D device B). Furthermore, the devices significantly decreased transdermal drug delivery compared to the control containing the free drug. Thus, the resulting systems are promising for producing 3D printed earring taps with topical drug delivery and reinforcing the feasibility of patient-centered drug administration through wearable devices.
Databáze: MEDLINE
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