Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay.

Autor: Vazquez C; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Fonseca V; Coordenação de Vigilância, Preparação e Resposta à Emergências e Desastres (PHE), Organização Pan-Americana da Saúde/Organização Mundial da Saúde (OPAS/OMS), Brasilia 70312-970, Brazil.; Department of Exact and Earth Sciences, University of the State of Bahia, Salvador 41150-000, Brazil., de la Fuente AG; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Gonzalez S; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Fleitas F; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Lima M; Laboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil., Guimarães NR; Laboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil., Iani FCM; Laboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil., Rojas A; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Alfonso T; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Cantero C; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Barrios J; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Villalba S; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Ortega MJ; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Torales J; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Gamarra ML; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Aquino C; Laboratorio Central de Salud Pública, Asunción 001535, Paraguay., Franco L; Infectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organization/World Health Organization (PAHO/WHO), Washington, DC 20037, USA., Rico JM; Infectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organization/World Health Organization (PAHO/WHO), Washington, DC 20037, USA., Alcantara LCJ; Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, Brazil.; Climate Amplified Diseases and Epidemics (CLIMADE), University of Washington, Seattle, WA 98195, USA., Giovanetti M; Climate Amplified Diseases and Epidemics (CLIMADE), University of Washington, Seattle, WA 98195, USA.; Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia 40296-710, Brazil.; Sciences and Technologies for Sustainable Development and One Health, University of Campus Bio-Medico, 00128 Rome, Italy.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2024 Jan 04; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 04.
DOI: 10.3390/v16010083
Abstrakt: In recent months, Paraguay has been grappled with a notable monkeypox outbreak, straining its healthcare infrastructure. The sudden spike in cases underlines the imperative need for a comprehensive understanding of the virus's dynamics, enabling the formulation of robust containment measures. To address this challenge, our team joined forces with the Central Public Health Laboratory of Asunción and the Pan-American Health Organization. Through this collaboration, we employed portable whole-genome sequencing combined with phylodynamic analysis to examine the MPXV strains circulating in Paraguay. Our genomic monitoring approach has produced the first 30 whole-genome sequences from Paraguay, all of which were identified under lineage IIb. Interestingly, our data suggest that the origin of the monkeypox virus in Paraguay at the beginning of 2022 can be traced back to Brazil. This introduction subsequently catalyzed further community spread that was further exacerbated by several independent introduction events as time progressed. These findings not only shed light on the transmission patterns of the virus but also highlight the pivotal role such insights play in sculpting effective response strategies and driving impactful public health measures. Furthermore, our findings strongly advocate intensified surveillance at international borders, ensuring swift detection and proactive countermeasures against potential outbreaks in the future.
Databáze: MEDLINE
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