Thyroid Disorders in Systemic Sclerosis: A Comprehensive Review.

Autor: Cherim A; Department of Dermatovenerology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Internal Medicine 3rd Department, Colentina Clinical Hospital, 020123 Bucharest, Romania., Petca RC; Department of Urology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Urology, 'Prof. Dr. Th. Burghele' Clinical Hospital, 050659 Bucharest, Romania., Dumitrascu MC; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Obstetrics and Gynecology, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania., Petca A; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Obstetrics and Gynecology, Elias Emergency University Hospital, 011461 Bucharest, Romania., Candrea E; Department of Dermatology, University of Medicine and Pharmacy 'I. Hatieganu', 400347 Cluj Napoca, Romania., Sandru F; Department of Dermatovenerology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Dermatology Department, 'Elias' University Emergency Hospital, 011461 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Jan 11; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 11.
DOI: 10.3390/jcm13020415
Abstrakt: Systemic sclerosis, also referred to as scleroderma, is a chronic autoimmune disease that affects both internal organs and the skin. Systemic sclerosis predominantly affects female patients and can coexist with other disorders, including those affecting the thyroid gland. Common symptoms such as fatigue and weight changes can be attributed to either systemic sclerosis or thyroid disease. In this comprehensive review, an extensive analysis is conducted using research from 2002 to 2022, sourced from PubMed. The main focus of this exploration is to understand the intricate relationship between thyroid disorders and systemic sclerosis. We obtained these results by analyzing a number of 32285 patients included in 21 original studies. The existing evidence suggests that there is a higher incidence of elevated TSH levels and hypothyroidism in patients with systemic sclerosis, particularly in females, compared to the general population. This remains true even when comparing patients from iodine-deficient regions. Additionally, there is an increased occurrence of hyperthyroidism in the context of systemic sclerosis, which negatively impacts the prognosis of these patients. Furthermore, thyroid antibodies, predominantly anti-thyroid peroxidase (anti-TPO) antibodies, and autoimmune disorders are more commonly observed in individuals with systemic sclerosis. Although thyroid nodules are not specifically linked to the disease, when considering thyroid volume, it is observed that the thyroid gland in systemic sclerosis patients has a decreased volume, possibly due to fibrosis. Conversely, other studies have revealed that patients without autoimmune thyroid diseases (AITDs) are more likely to have a history of digital ulcers, pulmonary fibrosis detected by computed tomography scan, and a requirement for immunosuppressive medication. The majority of the studies did not establish a connection between thyroid disease in these patients and the occurrence of the limited or diffuse forms of systemic sclerosis, as well as the presence of digital ulcers, calcinosis, pulmonary arterial hypertension, scleroderma renal crisis, Raynaud phenomenon, and various other clinical manifestations.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje