| Autor: |
Güllüoğlu H; Department of Neurology, Izmir Ekonomi University Medical Point Hospital, Izmir 35080, Turkey., Hünerli D; Department of Neuroscience, Dokuz Eylul University Institute Health Sciences, Izmir 35210, Turkey., Çakmur R; Department of Neurology, Dokuz Eylul University School of Medicine, Izmir 35210, Turkey., Çolakoğlu BD; Department of Neurology, Dokuz Eylul University School of Medicine, Izmir 35210, Turkey., Ada E; Department of Radiology, Dokuz Eylul University School of Medicine, Izmir 35210, Turkey., Yener G; Izmir Biomedicine and Genome Center, Izmir 35340, Turkey.; Department of Neurolohy, Faculty of Medicine, Izmir University of Economics, Izmir 35330, Turkey. |
| Abstrakt: |
Background and Objectives: The pathophysiology of mild cognitive impairment in Parkinson's disease (PD-MCI) is still not fully elucidated. It has been shown in a few studies in the literature that volume loss in the occipital, parietal and frontal cortices and atrophy in the hippocampus of PD-MCI patients can occur in the early stages of PD. The aim of this study was to evaluate the relationship between gray and white matter volumes and different neuropsychological tests and volumetric magnetic resonance imaging parameters in patients with mild cognitive impairment in Parkinson's disease (PD-MCI). Materials and Methods: Twenty-six PD-MCI and twenty-six healthy elderly (HC) were included in this study. Results: We found that Mini Mental State Examination, Trail Making Test Part A, Clock Drawing Test, Benton Line Judgment Orientation Test and pentagon figure-copying scores were impaired in PD-MCI patients due to the decrease in brain volumes. Conclusions: Our study revealed that among PD-MCI patients, there was a more noticeable decline in White matter volume (WMV) based on volumetric Magnetic Resonance Imaging (MRI) compared to the localized loss of GMV. We think that these abnormal neuropsychological tests in PD-MCI patients can be used as pretests in the evaluation of the stage of transition to dementia. |
