COVID-19 Crisis in Brazil: Post-Vaccination Seroprevalence and Infection in More and Less Vaccinated Municipalities in a Northeastern State.

Autor: Santos RS; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Barreto MDS; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Silva EED; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Silva BSD; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Jesus PC; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Silva DMRR; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Moura PHM; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Souza JB; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Santos LMMD; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Guimarães AG; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Santana LADM; Graduate Program in Dentistry, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil., Borges LP; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2024 Jan 08; Vol. 14 (1). Date of Electronic Publication: 2024 Jan 08.
DOI: 10.3390/life14010094
Abstrakt: Background: Given the impact of the pandemic in Brazil, vaccination is essential to prevent illness and death. Thus, this study sought to compare, after vaccination, the circulation of SARS-CoV-2 and the response to vaccination in the least and most vaccinated municipalities of a Brazilian state during the height of the pandemic when the Omicron variant was dominant.
Methods: We tested for the SARS-CoV-2 antigen and confirmed infection using an RT-qPCR and measured IgM and IgG antibodies in fully vaccinated participants from municipalities with higher and lower vaccination rates.
Results: We showed that participants from the least vaccinated municipalities were more likely to have detectable IgM antibodies and a positive antigen/RT-qPCR result for SARS-CoV-2 than participants from the most vaccinated municipalities. There were no differences between the vaccines used (BNT162b2, Ad26.COV2.S, AZD1222, and CoronaVac) and antibody production.
Conclusions: Our study evaluated municipal vaccination coverage and its effects on mortality, infections, and anti-SARS-CoV-2 antibodies during a critical phase of the pandemic. The results suggest that higher vaccination coverage reduces acute cases and confers higher memory antibody levels against SARS-CoV-2. Even with a full vaccination schedule, individuals living in places with low vaccination rates are more susceptible to infection.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje