Super-Resolution Ultrasound Reveals Cerebrovascular Impairment in a Mouse Model of Alzheimer's Disease.

Autor:	Lowerison MR; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.; Departments of Electrical and Computer Engineering, Urbana, Illinois 61801., Vaithiyalingam Chandra Sekaran N; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.; Molecular and Integrative Physiology, Urbana, Illinois 61801., Dong Z; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.; Departments of Electrical and Computer Engineering, Urbana, Illinois 61801., Chen X; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.; Departments of Electrical and Computer Engineering, Urbana, Illinois 61801., You Q; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.; Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Llano DA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 d-llano@illinois.edu songp@illinois.edu.; Molecular and Integrative Physiology, Urbana, Illinois 61801.; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Song P; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 d-llano@illinois.edu songp@illinois.edu.; Departments of Electrical and Computer Engineering, Urbana, Illinois 61801.; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Feb 28; Vol. 44 (9). Date of Electronic Publication: 2024 Feb 28.
DOI:	10.1523/JNEUROSCI.1251-23.2024
Abstrakt:	Increasing evidence has suggested a link between cerebrovascular disease and the cognitive impairment associated with Alzheimer's disease. However, detailed descriptions of microvascular changes across brain regions and how they relate to other more traditional pathology have been lacking. Additionally, the efforts to elucidate the interplay between cerebral microvascular function and Alzheimer's disease progression are complicated by the necessity of probing deep-brain structures since early-stage Alzheimer's disease typically involves hippocampal pathology. The purpose of this study was to examine changes in microvascular dynamics in a mouse model of Alzheimer's disease using cohorts that were age-matched to wild-type controls. Data from both sexes were included in this study. Super-resolution ultrasound localization microscopy revealed microvascular functional and structural features throughout the whole brain depth to visualize and quantify. We found that functional decreases in hippocampal and entorhinal flow velocity preceded structural derangements in regional vascular density. Co-registered histological sectioning confirmed the regionalized perfusion deficits seen on ultrasound imaging, which were co-localized with amyloid beta plaque deposition. In addition to providing global vascular quantifications of deep brain structures with a high local resolution, this technology also permitted velocity-profile analysis of individual vessels and, in some cases, allowed for decoupling of arterial and venous flow contributions. These data suggest that microvascular pathology is an early and pervasive feature of Alzheimer's disease and may represent a novel therapeutic target for this disease. (Copyright © 2024 Lowerison et al.)
Databáze:	MEDLINE
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