Anti-inflammatory constituents from a sea anemone-derived fungus Arthrinium arundinis MA30.

Autor: Lee YS; Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 106, Taiwan. Electronic address: r09b45017@ntu.edu.tw., Wu HC; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan; Ph.D. Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: hochengwu@tmu.edu.tw., Huang SJ; Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 106, Taiwan. Electronic address: f08b45018@ntu.edu.tw., Hsiao G; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. Electronic address: geohsiao@tmu.edu.tw., Chi WC; Department of Food Science, National Quemoy University, Kinmen 892, Taiwan. Electronic address: joan@nqu.edu.tw., Lee TH; Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 106, Taiwan. Electronic address: thlee1@ntu.edu.tw.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2024 Mar; Vol. 219, pp. 113998. Date of Electronic Publication: 2024 Jan 20.
DOI: 10.1016/j.phytochem.2024.113998
Abstrakt: In this study, preliminary field-sampling of bioactive fungal strains and bioassay-guided selection were conducted. A number of fungal strains were isolated from sea anemones along the northeastern coast of Badouzi, Keelung, Taiwan. Among them, Arthrinium arundinis MA30 showed significant anti-inflammatory activity and was thus selected for further chemical investigation. After a series of purification and isolation using different chromatographic techniques on the fermented products of A. arundinis MA30, thirty-one compounds were identified, five of which were previously unreported, including arthrinoic acid, hexylaconitic anhydride methyl ester, (3S,8R)-8-hydroxy-3-carboxy-2-methylenenonanoic acid, and arthripenoids G and H. These compounds were subjected to comprehensive spectroscopic data analysis. Of all the isolates, 1,3,5,6-tetrahydroxy-8-methylxanthone and arthripenoid C demonstrated the most distinctive inhibitory activities against nitric oxide production in mouse microglial BV-2 cells, with their respective inhibitory rates being 71% and 81% at 10 μM concentration, and their respective IC 50 values were further determined to be 5.3 ± 0.6 and 1.6 ± 0.4 μM. These compounds showed no significant cytotoxicity, and curcumin was used as a positive control in this study.
Competing Interests: Declaration of competing interest ☑The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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