Cerebral Microvascular Perfusion Assessed in Elderly Adults by Spin-Echo Dynamic Susceptibility Contrast MRI at 7 Tesla.

Autor: Elschot EP; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.; MHeNs School for Mental Health and Neuroscience, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands., Backes WH; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.; MHeNs School for Mental Health and Neuroscience, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands., van den Kerkhof M; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.; MHeNs School for Mental Health and Neuroscience, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands., Postma AA; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.; MHeNs School for Mental Health and Neuroscience, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands., Kroon AA; CARIM School for Cardiovascular Diseases, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands.; Department of Internal Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands., Jansen JFA; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.; MHeNs School for Mental Health and Neuroscience, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands.; Department of Electrical Engineering, Eindhoven University of Technology, De Rondom 70, P.O. Box 513, 5612 AP Eindhoven, The Netherlands.
Jazyk: angličtina
Zdroj: Tomography (Ann Arbor, Mich.) [Tomography] 2024 Jan 18; Vol. 10 (1), pp. 181-192. Date of Electronic Publication: 2024 Jan 18.
DOI: 10.3390/tomography10010014
Abstrakt: Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated. Higher CBV and CBF values were found in CGM compared to WM, whereby the CGM-to-WM ratios depended on the amount of largest vessels excluded from the analysis. CBF was negatively associated with age in the CGM, while no significant association was found with CBV. Both CBV and CBF were higher in women compared to men in both CGM and WM. The current study verifies the possibility of quantifying cerebral microvascular perfusion with SE-DSC MRI at 7 T.
Databáze: MEDLINE
Externí odkaz: