Differences in Responses of Immunosuppressed Kidney Transplant Patients to Moderna mRNA-1273 versus Pfizer-BioNTech.

Autor: Bekbolsynov D; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Waack A; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Buskey C; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Bhadkamkar S; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Rengel K; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Petersen W; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Brown ML; Department of Urology, University of Toledo, Toledo, OH 43614, USA., Sparkle T; Department of Anesthesiology, University of Toledo, Toledo, OH 43614, USA., Kaw D; Department of Internal Medicine, University of Toledo, Toledo, OH 43614, USA., Syed FJ; Department of Electrical Engineering and Computer Science, University of Toledo, Toledo, OH 43614, USA., Chattopadhyay S; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Chakravarti R; Department of Physiology, University of Toledo, Toledo, OH 43614, USA., Khuder S; Department of Internal Medicine, University of Toledo, Toledo, OH 43614, USA., Mierzejewska B; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA., Rees M; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.; Department of Urology, University of Toledo, Toledo, OH 43614, USA., Stepkowski S; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
Jazyk: angličtina
Zdroj: Vaccines [Vaccines (Basel)] 2024 Jan 17; Vol. 12 (1). Date of Electronic Publication: 2024 Jan 17.
DOI: 10.3390/vaccines12010091
Abstrakt: Immunosuppressed kidney transplant (KT) recipients produce a weaker response to COVID-19 vaccination than immunocompetent individuals. We tested antiviral IgG response in 99 KT recipients and 66 healthy volunteers who were vaccinated with mRNA-1273 Moderna or BNT162b2 Pfizer-BioNTech vaccines. A subgroup of participants had their peripheral blood leukocytes (PBLs) evaluated for the frequency of T helper 1 (Th1) cells producing IL-2, IFN-γ and/or TNF-α, and IL-10-producing T-regulatory 1 (Tr) cells. Among KT recipients, 45.8% had anti-SARS-CoV-2 IgG compared to 74.1% of healthy volunteers ( p = 0.009); also, anti-viral IgG levels were lower in recipients than in volunteers ( p = 0.001). In terms of non-responders (≤2000 U/mL IgG), Moderna's group had 10.8% and Pfizer-BioNTech's group had 34.3% of non-responders at 6 months ( p = 0.023); similarly, 15.7% and 31.3% were non-responders in Moderna and Pfizer-BioNTech groups at 12 months, respectively ( p = 0.067). There were no non-responders among controls. Healthy volunteers had higher Th1 levels than KT recipients, while Moderna produced a higher Th1 response than Pfizer-BioNTech. In contrast, the Pfizer-BioNTech vaccine induced a higher Tr1 response than the Moderna vaccine ( p < 0.05); overall, IgG levels correlated with Th1(fT TNF-α )/Tr1(fT IL-10 ) ratios. We propose that the higher number of non-responders in the Pfizer-BioNTech group than the Moderna group was caused by a more potent activity of regulatory Tr1 cells in KT recipients vaccinated with the Pfizer-BioNTech vaccine.
Databáze: MEDLINE
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