Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial.

Autor:	Carracedo-Sanchidrian D; Department of Psychiatry, University Hospital La Paz, Madrid, Spain.; La Paz Hospital Institute for Health Research (IdiPAZ), Madrid, Spain., de Dios-Perrino C; Department of Psychiatry, University Hospital La Paz, Madrid, Spain.; La Paz Hospital Institute for Health Research (IdiPAZ), Madrid, Spain.; Autonomous University of Madrid (UAM), Madrid, Spain., Bayon-Perez C; Department of Psychiatry, University Hospital La Paz, Madrid, Spain.; La Paz Hospital Institute for Health Research (IdiPAZ), Madrid, Spain.; Autonomous University of Madrid (UAM), Madrid, Spain., Rodriguez-Vega B; Department of Psychiatry, University Hospital La Paz, Madrid, Spain.; La Paz Hospital Institute for Health Research (IdiPAZ), Madrid, Spain.; Autonomous University of Madrid (UAM), Madrid, Spain., Bravo-Ortiz MF; Department of Psychiatry, University Hospital La Paz, Madrid, Spain.; La Paz Hospital Institute for Health Research (IdiPAZ), Madrid, Spain.; Autonomous University of Madrid (UAM), Madrid, Spain., Ortega MÁ; Faculty of Medicine and Health Sciences, University of Alcalá, Madrid, Spain.; CIBERSAM, Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain., González-Pinto AM; BIOARABA, UPV/EHU, CIBERSAM, Department of Psychiatry, Hospital Santiago Apostol, Vitoria, Spain., Lahera G; Faculty of Medicine and Health Sciences, University of Alcalá, Madrid, Spain.; CIBERSAM, Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.; Principe de Asturias University Hospital, Alcalá, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2024 Jan 05; Vol. 14, pp. 1279342. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2023).
DOI:	10.3389/fpsyt.2023.1279342
Abstrakt:	Introduction: Few controlled trials have assessed the benefits of Mindfulness Based Cognitive Therapy (MBCT) on cognitive functions and brain-derived neurotrophic factor (BDNF) in bipolar disorder (BD). This study aims to evaluate the impact of MBCT adjunctive treatment on these variables. Main hypothesis was that MBCT would improve cognitive functioning and BDNF more than Psychoeducation and TAU. Methods: Randomized, multicenter, prospective and single-blinded trial. Included BD outpatients randomly assigned to three treatment arms: MBCT plus treatment as usual (TAU), Psychoeducation plus Tau and TAU. Cognitive functions were assessed with Continuous Performance Test-III, Stroop Test, Trail Making Test, Digit Span and Letter-Number Sequencing from Wechsler Adult Intelligence Scale III, Face Emotion Identification Task and Face Emotion Discrimination Task. BDNF serum level was measured with ELISA. Patients were assessed at baseline, 8 weeks and 6 months. Results: Eighty-four patients were recruited (TAU = 10, Psychoeducation = 34, MBCT = 40). No significant differences between treatment groups were found. MBCT does not achieve better results than Psychoeducation or TAU. Discussion: Being Psychoeducation and TAU efficient interventions, as well as the scarce duration of a more complex intervention, such as MBCT, are suggested as explanatory variables of these results. Trial Registration: ClinicalTrials.gov: NCT02133170. Registered 04/30/2014. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Carracedo-Sanchidrian, de Dios-Perrino, Bayon-Perez, Rodriguez-Vega, Bravo-Ortiz, Ortega, González-Pinto and Lahera.)
Databáze:	MEDLINE
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