Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir.

Autor:	De Clercq J; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium., De Scheerder MA; Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium., Mortier V; Department of Diagnostic Sciences, Aids Reference Laboratory, Ghent University, Ghent, Belgium., Verhofstede C; Department of Diagnostic Sciences, Aids Reference Laboratory, Ghent University, Ghent, Belgium., Vandecasteele SJ; Department of Nephrology and Infectious Diseases, AZ Sint-Jan, Bruges, Belgium., Allard SD; Department of Internal Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium., Necsoi C; Department of Infectious Diseases, Saint-Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium., De Wit S; Department of Infectious Diseases, Saint-Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium., Gerlo S; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Jan 05; Vol. 14, pp. 1337316. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1337316
Abstrakt:	Background: Despite the beneficial effects of antiretroviral therapy (ART) initiation during acute HIV infection (AHI), residual immune activation remains a hallmark of treated HIV infection. Methods: Plasma concentrations of 40 mediators were measured longitudinally in 39 early treated participants of a Belgian AHI cohort (HIV+) and in 21 HIV-negative controls (HIV-). We investigated the association of the inflammatory profile with clinical presentation, plasma viral load, immunological parameters, and in-depth characterization of the HIV reservoir. Results: While levels of most soluble mediators normalized with suppressive ART, we demonstrated the persistence of a pro-inflammatory signature in early treated HIV+ participants in comparison to HIV- controls. Examination of these mediators demonstrated a correlation with their levels during AHI, which seemed to be viremia-driven, and suggested involvement of an activated myeloid compartment, IFN-γ-signaling, and inflammasome-related pathways. Interestingly, some of these pro-inflammatory mediators correlated with a larger reservoir size and slower reservoir decay. In contrast, we also identified soluble mediators which were associated with favorable effects on immunovirological outcomes and reservoir, both during and after AHI. Conclusion: These data highlight how the persistent pro-inflammatory profile observed in early ART treated individuals is shaped during AHI and is intertwined with viral dynamics. Competing Interests: LV has received consulting fees and travel grants from Gilead Sciences and ViiV Healthcare, paid to his institution. JDC and SG have received travel grants from ViiV Healthcare. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 De Clercq, De Scheerder, Mortier, Verhofstede, Vandecasteele, Allard, Necsoi, De Wit, Gerlo and Vandekerckhove.)
Databáze:	MEDLINE
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