SYNTHETIC APPROACHES TO 4,8-DIMETHYL-4'- ( N -PYRIDINIUMMETHYL)- 4',5'-DIHYDROPSORALENS AND THEIR ACTIVITY AGAINST PAM 212 KERATINOCYTES.

Autor: Whittemore MS; Department of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, PA 18015, U. S. A.; Buckman Laboratories, 1256 North McLean Blvd., Memphis, TN 38108, U. S. A., Heindel ND; Buckman Laboratories, 1256 North McLean Blvd., Memphis, TN 38108, U. S. A., Guillon CD; Buckman Laboratories, 1256 North McLean Blvd., Memphis, TN 38108, U. S. A., McNeel TE; Department of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, PA 18015, U. S. A., Rapp RD; Department of Chemistry, Albright College, P.O. Box 15234, Reading, PA 19612-5234, U. S. A., Mariano TM; Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, U. S. A., Heck DE; Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, U. S. A., Laskin JD; Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, U. S. A.
Jazyk: angličtina
Zdroj: Heterocycles [Heterocycles] 2001; Vol. 55 (6), pp. 1081-1093.
DOI: 10.3987/com-01-9197
Abstrakt: Synthetic approaches to novel 4,8-dimethyl-4'-halomethyl-4',5'-dihydropsoralens as synthetic precursors to 4,8-dimethyl-4'-( N -pyridiniummethyl)-4',5'-dihydropsoralens are described. The compounds are potential therapeutic agents for improved psoralen ultraviolet radiation therapy with reduced mutagenicity.
Databáze: MEDLINE