| Autor: |
Roman AM; Dermatology Department, 'Elias' University Emergency Hospital, 011461 Bucharest, Romania., Petca RC; Department of Urology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Urology, 'Prof. Dr. Th. Burghele' Clinical Hospital, 050659 Bucharest, Romania., Dumitrașcu MC; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Obstetrics and Gynecology, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania., Petca A; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Obstetrics and Gynecology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania., Ionescu Miron AI; Department of Oncological Radiotherapy and Medical Imaging, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Medical Oncology, Colțea Clinical Hospital, 030167 Bucharest, Romania., Șandru F; Dermatology Department, 'Elias' University Emergency Hospital, 011461 Bucharest, Romania.; Department of Dermatovenerology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania. |
| Abstrakt: |
Frontal Fibrosing Alopecia (FFA) is a distinctive form of cicatricial alopecia characterized by gradual hairline recession, predominantly affecting postmenopausal individuals, thus implying a potential hormonal origin. This narrative review, spanning 2000 to 2023, delves into PubMed literature, focusing on the menopausal and hormonal status of women with FFA. The objective is to unravel the intricate nature of FFA and its plausible associations with hormonal dysregulations in women. While menopause remains a pivotal demographic characteristic linked to FFA, existing data suggest that its hormonal imbalances may not fully account for the development of FFA. Conversely, substantial evidence indicates a strong association between a reduction in fertile years, particularly through surgical interventions leading to an abrupt hormonal imbalance, and FFA in women. Additionally, exposure to hormone replacement therapy or oral contraceptives has shown varying degrees of association with FFA. Gynecologists should maintain a heightened awareness regarding the ramifications of their interventions and their pivotal role in overseeing women's fertility, recognizing the potential influence on the progression of FFA. The recurrent theme of hormonal disruption strongly implies a causal connection between alterations in sex hormones and FFA in women. Nevertheless, this relationship's extent and underlying mechanisms remain subjects of ongoing debate. |
