| Autor: |
Abdulghafor MA; College of Dentistry, University of Sulaimani, Sulaimani 46001, Kurdistan, Iraq., Mahmood MK; Faculty of Dentistry, Aix-Marseille University, CNRS, EFS, ADES, 13284 Marseille, France.; College of Dentistry, The American University of Iraq, Sulaimani 46001, Kurdistan, Iraq., Tassery H; LBN Laboratory, 34070 Montpellier, France., Tardivo D; Faculty of Dentistry, Aix-Marseille University, CNRS, EFS, ADES, 13284 Marseille, France., Falguiere A; Oral Surgery Department, Timone Hospital, Aix-Marseille University, APHM, 13284 Marseille, France., Lan R; Oral Surgery Department, Timone Hospital, Aix-Marseille University, APHM, CNRS, EFS, ADES, 13284 Marseille, France. |
| Abstrakt: |
Biomimetic dental implants are regarded as one of the recent clinical advancements in implant surface modification. Coatings with varying thicknesses and roughness may affect the dental implant surface's chemical inertness, cell adhesion, and antibacterial characteristics. Different surface coatings and mechanical surface changes have been studied to improve osseointegration and decrease peri-implantitis. The surface medication increases surface energy, leading to enhanced cell proliferation and growth factors, and, consequently, to a rise in the osseointegration process. This review provides a comprehensive update on the numerous biomimetic coatings used to improve the surface characteristics of dental implants and their applications in two main categories: coating to improve osseointegration, including the hydroxyapatite layer and nanocomposites, growth factors (BMPs, PDGF, FGF), and extracellular matrix (collagen, elastin, fibronectin, chondroitin sulfate, hyaluronan, and other proteoglycans), and coatings for anti-bacterial performance, covering drug-coated dental implants (antibiotic, statin, and bisphosphonate), antimicrobial peptide coating (GL13K and human beta defensins), polysaccharide antibacterial coatings (natural chitosan and its coupling agents) and metal elements (silver, zinc, and copper). |
