Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors-A Narrative Review.

Autor: Magnani L; Department of Psychiatry, San Maurizio Hospital, 39100 Bolzano, Italy., Aguglia A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.; IRCCS Polyclinic Hospital San Martino, 16132 Genoa, Italy., Alexander J; Department of Psychiatry, Geneva University Hospital (HUG), 1205 Geneva, Switzerland., Maiorano A; Department of Psychiatry, Geneva University Hospital (HUG), 1205 Geneva, Switzerland., Richard-Lepouriel H; Department of Psychiatry, Mood Disorder Unit, Psychiatric Specialties Service, Geneva University Hospital (HUG), 1205 Geneva, Switzerland., Iancau SP; Residence School in Psychiatry, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University, 00185 Rome, Italy., Amerio A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.; IRCCS Polyclinic Hospital San Martino, 16132 Genoa, Italy., Parise A; Geriatric-Rehabilitation Department, University Hospital of Parma, 43126 Parma, Italy., Serafini G; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.; IRCCS Polyclinic Hospital San Martino, 16132 Genoa, Italy., Amore M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.; IRCCS Polyclinic Hospital San Martino, 16132 Genoa, Italy., Nguyen KD; Chinese University of Hong Kong, Hong Kong SAR, China.; Tranquis Therapeutics, Palo Alto, CA 94303, USA., Costanza A; Department of Psychiatry, Geneva University Hospital (HUG), 1205 Geneva, Switzerland.; Department of Psychiatry, Faculty of Biomedical Sciences, University of Italian Switzerland (USI), 6900 Lugano, Switzerland.; Department of Psychiatry, Faculty of Medicine, Geneva University (UNIGE), 1205 Geneva, Switzerland.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2023 Dec 28; Vol. 14 (1). Date of Electronic Publication: 2023 Dec 28.
DOI: 10.3390/brainsci14010030
Abstrakt: A chronotype is generally defined as the variability of the phase angle of entrainment, while the latter reflects the relationship between the timing of a certain rhythm (e.g., the sleep-wake cycle) and the timing of an external temporal cue. Individuals can be placed on a spectrum from "morning types" (M types) to "evening types" (E types). E-chronotype has been proposed as a transdiagnostic risk factor for psychiatric conditions, and it has been associated with psychopathological dimensions. Eveningness seems to be correlated with both suicidal ideation (SI) and suicidal behavior (SB) through several possible mediating factors. Immunological alterations have also been linked to later chronotypes and SI/SB. This narrative review aims to summarize the evidence supporting the possible association between chronotypes and suicide and the eventual mediating role of neuroinflammation and several psychopathological dimensions. A search of the literature (2003-2023) was conducted using various databases: PUBMED, EMBASE, Scopus, UpToDate, PsycINFO, and Cochrane Library. English-language articles were collected and screened for eligibility. Despite the apparent absence of a direct correlation between E-chronotype and suicidality, E-chronotype promotes a chain of effects that could be involved in an increased risk of SB, in which with neuroinflammation possibly plays an intriguing role and some psychopathological dimensions may stand out.
Databáze: MEDLINE
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