| Autor: |
Biancotti JC; Department of Surgery/Pediatric Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Espinosa-Jeffrey A; Department of Psychiatry, IDDRC, Semel Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Bioengineering (Basel, Switzerland) [Bioengineering (Basel)] 2023 Dec 22; Vol. 11 (1). Date of Electronic Publication: 2023 Dec 22. |
| DOI: |
10.3390/bioengineering11010011 |
| Abstrakt: |
The change in gravitational force has a significant effect on biological tissues and the entire organism. As with any alteration in the environment, microgravity (µG) produces modifications in the system inducing adaptation to the new condition. In this study, we analyzed the effect of µG on neural stem cells (NSCs) following a space flight to the International Space Station (ISS). After 3 days in space, analysis of the metabolome in culture medium revealed increased glycolysis with augmented pyruvate and glycerate levels, and activated catabolism of branched-chain amino acids (BCAA) and glutamine. NSCs flown into space (SPC-NSCs) also showed increased synthesis of NADH and formation of polyamine spermidine when compared to ground controls (GC-NSCs). Overall, the space environment appears to increase energy demands in response to the µG setting. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
