Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study).

Autor:	Schüz J; International Agency for Research on Cancer-World Health Organization, Lyon, France., Kovalevskiy E; Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation.; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Olsson A; International Agency for Research on Cancer-World Health Organization, Lyon, France., Moissonnier M; International Agency for Research on Cancer-World Health Organization, Lyon, France., Ostroumova E; International Agency for Research on Cancer-World Health Organization, Lyon, France., Ferro G; International Agency for Research on Cancer-World Health Organization, Lyon, France., Feletto E; International Agency for Research on Cancer-World Health Organization, Lyon, France.; The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council New South Wales, Sydney, Australia., Schonfeld SJ; International Agency for Research on Cancer-World Health Organization, Lyon, France.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Byrnes G; International Agency for Research on Cancer-World Health Organization, Lyon, France., Tskhomariia I; Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation., Straif K; International Agency for Research on Cancer-World Health Organization, Lyon, France., Morozova T; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Kromhout H; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Bukhtiyarov I; Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation.; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Jun 07; Vol. 116 (6), pp. 866-875.
DOI:	10.1093/jnci/djad262
Abstrakt:	Background: We investigated mortality in workers of the world's largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation. Methods: This historical cohort study included all workers employed for at least 1 year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers' complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers was estimated using dust-to-fiber conversion factors. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated as mortality rate ratios in Poisson regression models. Results: A total of 30 445 (32% women) workers accumulated 721 312 person-years at risk and 11 110 (36%) died. Of the workers, 54% had more than 30 years since their first exposure. We found an exposure-response between cumulative dust and lung cancer mortality in men. No clear association with dust exposure but a modest increase in the highest category of fiber exposure was seen for lung cancer in women. Mesothelioma mortality was increased (RR = 7.64, 95% CI = 1.18 to 49.5, to at least 80 fibers per cm3 years and RR = 4.56, 95% CI = 0.94 to 22.1, to at least 150 mg/m3 years [dust]), based on 13 deaths. For colorectal and stomach cancer, there were inconsistent associations. No associations were seen for laryngeal or ovarian cancer. Conclusion: In this large-scale epidemiological study in the world's largest active asbestos mine, we confirmed an increased risk of mesothelioma with high fiber exposure and an increasing mortality for lung cancer in men with increasing dust exposure. Less clear-cut increased lung cancer mortality was seen in the women. Continued mortality follow-up is warranted. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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