Adverse Childhood Experiences and Related Events are Associated with Asthma Symptoms in Children.

Autor: Martinez A; University of California San Francisco, School of Medicine (A Martinez, Y Ye, D Hessler, R de la Rosa, and N Thakur)., Ye M; University of California San Francisco, School of Medicine (A Martinez, Y Ye, D Hessler, R de la Rosa, and N Thakur)., Hessler D; University of California San Francisco, School of Medicine (A Martinez, Y Ye, D Hessler, R de la Rosa, and N Thakur)., de la Rosa R; University of California San Francisco, School of Medicine (A Martinez, Y Ye, D Hessler, R de la Rosa, and N Thakur)., Benson M; UCSF Benioff Children's Hospital Oakland (M Benson and D Long), Oakland, Calif., Gilgoff R; Center for Youth Wellness (R Gilgoff, K Koita, M Bucci, and NB Harris), San Francisco, Calif., Koita K; Center for Youth Wellness (R Gilgoff, K Koita, M Bucci, and NB Harris), San Francisco, Calif., Bucci M; Center for Youth Wellness (R Gilgoff, K Koita, M Bucci, and NB Harris), San Francisco, Calif., Harris NB; Center for Youth Wellness (R Gilgoff, K Koita, M Bucci, and NB Harris), San Francisco, Calif., Long D; UCSF Benioff Children's Hospital Oakland (M Benson and D Long), Oakland, Calif., Thakur N; University of California San Francisco, School of Medicine (A Martinez, Y Ye, D Hessler, R de la Rosa, and N Thakur). Electronic address: Neeta.Thakur@ucsf.edu.
Jazyk: angličtina
Zdroj: Academic pediatrics [Acad Pediatr] 2024 May-Jun; Vol. 24 (4), pp. 669-676. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1016/j.acap.2024.01.010
Abstrakt: Objective: To examine the association between adverse childhood experiences (ACEs) and related events and asthma symptom burden in children.
Methods: This is a cross-sectional study of baseline data from 147 participants with asthma from a cohort of children enrolled in the Pediatric ACEs Screening and Resiliency Study. Participants completed the PEdiatric ACEs and Related Life Events Screener (PEARLS) tool, a 17-item questionnaire, capturing 3 domains of childhood adversity-child maltreatment, household challenges, and social context. Asthma symptom burden was assessed using the International Study of Asthma and Allergies in Childhood core questionnaire, which asks participants to identify the presence and frequency of severe wheezing that limits speech, wheezing with exercise, nocturnal wheezing, and nocturnal cough in the last 12 months. Using multivariable logistical regression models, we examined the relationship between reported PEARLS and asthma symptoms.
Results: Of children with asthma, 86% reported at least 1 adversity, with 48% reporting 4 or more. The odds of severe wheeze limiting speech increased by 19% with each additional reported adversity captured by the PEARLS tool (95% confidence intervals (CI) 1.01-1.41). Increasing PEARLS scores were also associated with 16% increased odds of reporting wheeze with exercise (95% CI 1.03-1.31). Wheezing with exercise was associated with the household challenges domain (odds ratio (OR) 1.34; 95% CI 1.05-1.72), while severe wheeze limiting speech was associated with the social context domain (OR 1.75; 95%CI 1.02-3.02).
Conclusions: Childhood adversities are associated with increased asthma symptom burden, suggesting the tool may be helpful in identifying children at risk for poorly controlled asthma.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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