Female mice prenatally exposed to valproic acid exhibit complex and prolonged social behavior deficits.

Autor: Maisterrena A; Université de Poitiers, Inserm, Laboratoire de Neurosciences Expérimentales et Cliniques U1084, Poitiers, France., de Chaumont F; Institut Pasteur, CNRS, Human Genetics and Cognitive Functions, Paris, France., Longueville JE; Université de Poitiers, Inserm, Laboratoire de Neurosciences Expérimentales et Cliniques U1084, Poitiers, France., Balado E; Université de Poitiers, Inserm, Laboratoire de Neurosciences Expérimentales et Cliniques U1084, Poitiers, France., Ey E; Université de Strasbourg, CNRS, Inserm, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France., Jaber M; Université de Poitiers, Inserm, Laboratoire de Neurosciences Expérimentales et Cliniques U1084, Poitiers, France; CHU de Poitiers, Poitiers, France. Electronic address: mohamed.jaber@univ-poitiers.fr.
Jazyk: angličtina
Zdroj: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2024 Apr 20; Vol. 131, pp. 110948. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1016/j.pnpbp.2024.110948
Abstrakt: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized mainly by deficits in social communication and stereotyped and restricted behavior and interests with a male to female bias of 4.2/1. Social behavior in ASD animal models is commonly analyzed in males, and seldomly in females, using the widely implemented three-chambers test procedure. Here, we implemented a novel procedure, the Live Mouse Tracker (LMT), combining artificial intelligence, machine learning procedures and behavioral measures. We used it on mice that were prenatally exposed to valproic acid (VPA) (450 mg/kg) at embryonic day 12.5, a widely recognized and potent ASD model that we had previously extensively characterized. We focused on female mice offspring, in which social deficits have been rarely documented when using the 3-CT procedure. We recorded several parameters related to social behavior in these mice, continuously for three days in groups of four female mice. Comparisons were made on groups of 4 female mice with the same treatment (4 saline or 4 VPA) or with different treatments (3 saline and 1 VPA). We report that VPA females show several types of social deficits, which are different in nature and magnitude in relation with time. When VPA mice were placed in the LMT alongside saline mice, their social deficits showed significant improvement as early as 1 h from the start of the experiment, lasting up to 3 days throughout the duration of the experiment. Our findings suggest that ASD may be underdiagnosed in females. They also imply that ASD-related social deficits can be ameliorated by the presence of typical individuals.
Competing Interests: Declaration of competing interest Authors declare no financial interests that are directly or indirectly related to this work. Authors did not use AI assistance in writing of the manuscript.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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