Immunoregulatory function of SP-A.

Autor: Dong S; Department of Immunology, School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Anhui 233030, China., Pang H; Department of Immunology, School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Anhui 233030, China., Li F; Department of Immunology, School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Anhui 233030, China., Hua M; Department of Immunology, School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Anhui 233030, China., Liang M; Department of Biotechnology, School of Life Science, Bengbu Medical University, Anhui 233030, China. Electronic address: lmhk@mail.ustc.edu.cn., Song C; Department of Immunology, School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Anhui 233030, China. Electronic address: bbmcscw@foxmail.com.
Jazyk: angličtina
Zdroj: Molecular immunology [Mol Immunol] 2024 Feb; Vol. 166, pp. 58-64. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1016/j.molimm.2024.01.005
Abstrakt: Surfactant protein A (SP-A), a natural immune molecule, plays an important role in lung health. SP-A recognizes and binds microbial surface glycogroups through the C-type carbohydrate recognition domain, and then binds corresponding cell surface receptors (such as C1qRp, CRT-CD91 complex, CD14, SP-R210, Toll-like receptor, SIRP-α, CR3, etc.) through collagen-like region, and subsequently mediates biological effects. SP-A regulates lung innate immunity by promoting surfactant absorption by alveolar type II epithelial cells and phagocytosis of pathogenic microorganisms by alveolar macrophages. SP-A also regulates lung adaptive immunity by inhibiting DC maturation, and T cell proliferation and differentiation. This article reviews latest relationships between SP-A and adaptive and intrinsic immunity.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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