Dementia exacerbates periodontal bone loss in females.

Autor: Yamada C; Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, Indiana, USA.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana, USA., Ho A; Institute of Neuro-immune Medicine, Nova Southeastern University, Ft. Lauderdale, Florida, USA., Garcia C; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana, USA., Oblak AL; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA., Bissel S; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Porosencova T; Faculty of Dentistry, 'Nicolae Testemițanu' State University of Medicine and Pharmacy, Chisinau, Moldova., Porosencov E; Faculty of Dentistry, 'Nicolae Testemițanu' State University of Medicine and Pharmacy, Chisinau, Moldova., Uncuta D; Faculty of Dentistry, 'Nicolae Testemițanu' State University of Medicine and Pharmacy, Chisinau, Moldova., Ngala B; Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, Indiana, USA.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana, USA., Shepilov D; Department of Cytology, Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine., Skibo G; Department of Cytology, Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine., Mascarenhas AK; College of Graduate Health Studies, A.T. Still University, Kirksville, Missouri, USA., Akkaoui J; Institute of Neuro-immune Medicine, Nova Southeastern University, Ft. Lauderdale, Florida, USA.; Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA., Lakshmana MK; Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA., Sankar U; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Nichols F; Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA., Lamb BT; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Groppa S; Department of Neurology, Institute of Emergency Medicine, Chisinau, Moldova.; Department of Neurology, 'Nicolae Testemițanu' State University of Medicine and Pharmacy, Chisinau, Moldova., Movila A; Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, Indiana, USA.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Institute of Neuro-immune Medicine, Nova Southeastern University, Ft. Lauderdale, Florida, USA.; Department of Oral Sciences and Translational Research, College of Dental Medicine, Nova Southeastern University, Davie, Florida, USA.
Jazyk: angličtina
Zdroj: Journal of periodontal research [J Periodontal Res] 2024 Jun; Vol. 59 (3), pp. 512-520. Date of Electronic Publication: 2024 Jan 20.
DOI: 10.1111/jre.13227
Abstrakt: Background: Periodontitis is a chronic inflammatory disease defined by the pathologic loss of the periodontal ligament and alveolar bone in relation to aging. Although clinical cohort studies reported that periodontitis is significantly elevated in males compared to females, emerging evidence indicates that females with dementia are at a greater risk for periodontitis and decreased alveolar bone.
Objective: This study aimed to evaluate whether dementia is a potential sex-dependent risk factor for periodontal bone loss using an experimental model of periodontitis induced in the triple transgenic (3x-Tg) dementia-like mice and clinical samples collected from senior 65 plus age patients with diagnosed dementia.
Materials and Methods: We induced periodontitis in dementia-like triple-transgenic (3x-Tg) male and female mice and age-matched wild-type (WT) control mice by ligature placement. Then, alveolar bone loss and osteoclast activity were evaluated using micro-CT and in situ imaging assays. In addition, we performed dental examinations on patients with diagnosed dementia. Finally, dementia-associated Aβ42 and p-Tau (T181) and osteoclastogenic receptor activator of nuclear factor kappa-Β ligand (RANKL) in gingival crevicular fluid (GCF) collected from mice and clinical samples were measured by enzyme-linked immunosorbent assay (ELISA).
Results: Alveolar bone loss and in situ osteoclast activity were significantly elevated in periodontal lesions of 3x-Tg females but not males, compared to wild-type control mice. In addition, we also observed that the probing pocket depth (PPD) was also significantly elevated in female patients with dementia. Using ELISA assay, we observed that females had elevated levels of osteoclastogenic RANKL and dementia-associated Aβ42 and p-Tau (T181) in the GCF collected from experimental periodontitis lesions and clinical samples.
Conclusion: Altogether, we demonstrate that females with dementia have an increased risk for periodontal bone loss compared to males.
(© 2024 The Authors. Journal of Periodontal Research published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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