Altered grey matter structural covariance in chronic moderate-severe traumatic brain injury.

Autor: Symons GF; Department of Neuroscience, Monash University, 6th Floor, The Alfred Centre, 99 Commercial Road, Melbourne, VIC, 3004, Australia. Georgia.Fullersymons1@monash.edu., Gregg MC; Monash-Epworth Rehabilitation Research Centre, Ground Floor, 185-187 Hoddle St, Richmond, 3121, Australia., Hicks AJ; Monash-Epworth Rehabilitation Research Centre, Ground Floor, 185-187 Hoddle St, Richmond, 3121, Australia., Rowe CC; Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Rd, Heidelberg, VIC, 3084, Australia., Shultz SR; Department of Neuroscience, Monash University, 6th Floor, The Alfred Centre, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Health Sciences, Vancouver Island University, 900 Fifth Street, Nanaimo, BC, V9R 5S5, Canada., Ponsford JL; Monash-Epworth Rehabilitation Research Centre, Ground Floor, 185-187 Hoddle St, Richmond, 3121, Australia., Spitz G; Department of Neuroscience, Monash University, 6th Floor, The Alfred Centre, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Monash-Epworth Rehabilitation Research Centre, Ground Floor, 185-187 Hoddle St, Richmond, 3121, Australia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jan 19; Vol. 14 (1), pp. 1728. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1038/s41598-023-50396-7
Abstrakt: Traumatic brain injury (TBI) alters brain network connectivity. Structural covariance networks (SCNs) reflect morphological covariation between brain regions. SCNs may elucidate how altered brain network topology in TBI influences long-term outcomes. Here, we assessed whether SCN organisation is altered in individuals with chronic moderate-severe TBI (≥ 10 years post-injury) and associations with cognitive performance. This case-control study included fifty individuals with chronic moderate-severe TBI compared to 75 healthy controls recruited from an ongoing longitudinal head injury outcome study. SCNs were constructed using grey matter volume measurements from T1-weighted MRI images. Global and regional SCN organisation in relation to group membership and cognitive ability was examined using regression analyses. Globally, TBI participants had reduced small-worldness, longer characteristic path length, higher clustering, and higher modularity globally (p < 0.05). Regionally, TBI participants had greater betweenness centrality (p < 0.05) in frontal and central areas of the cortex. No significant associations were observed between global network measures and cognitive ability in participants with TBI (p > 0.05). Chronic moderate-severe TBI was associated with a shift towards a more segregated global network topology and altered organisation in frontal and central brain regions. There was no evidence that SCNs are associated with cognition.
(© 2024. The Author(s).)
Databáze: MEDLINE
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