The role of turmeric and black pepper oil nanoemulsion in attenuating cytokine storm triggered by duck hepatitis A virus type I (DHAV-I)-induced infection in ducklings.

Autor:	El-Sayed HS; Department of Poultry Diseases, Animal Health Research Institute, Benha-Branch, Agriculture Research Center (ARC), Benha 12618, Egypt., Saad AS; Biotechnology Department, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt., Tawfik WA; Holding Company for Biological Products and Vaccines, Dokki, Giza 12311, Egypt; NaQaa Nanotechnology Network (NNN), Giza, Egypt., Adel A; Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt., Abdelmagid MA; Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt., Momenah MA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Azab DM; Biochemistry Department (Pharmacology), Animal Health Research Institute, Benha-Branch, Agriculture Research Center (ARC), Benha 12618, Egypt., Omar SE; Department of Poultry Diseases, Animal Health Research Institute, Benha-Branch, Agriculture Research Center (ARC), Benha 12618, Egypt., El-Habbaa AS; Department of Virology, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Qalyubia, Egypt., Bahshwan SMA; Biological Sciences Department, College of Science and Arts, King Abdulaziz University, Rabigh 21911, Saudi Arabia., Alghamdi AM; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., El-Saadony MT; Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt., El-Tarabily KA; Department of Biology, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates. Electronic address: ktarabily@uaeu.ac.ae., El-Mayet FS; Department of Virology, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Qalyubia, Egypt; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
Jazyk:	angličtina
Zdroj:	Poultry science [Poult Sci] 2024 Mar; Vol. 103 (3), pp. 103404. Date of Electronic Publication: 2023 Dec 27.
DOI:	10.1016/j.psj.2023.103404
Abstrakt:	The cytokine storm induced by duck hepatitis A virus type 1 (DHAV-1) infection significantly contributes to severe, rapid deaths and economic losses in the duck industry in Egypt. This study aimed to investigate the potential inhibitory effect of a nanoemulsion containing turmeric and black pepper oil on the immune response and pathogenesis of DHAV-1 in ducklings. A total of 105 ducklings from nonvaccinated breeders were divided into 5 experimental groups, each comprising 21 birds. The negative control group (G1) remained noninfected with DHAV-1 and nontreated with nanoemulsion, while the positive control group (G2) was infected with DHAV-1 but not treated with nanoemulsion. The other 2 groups (G3, the supplemented group which was noninfected with DHAV-1), and group 4 (the prophylactic group G4) which was infected with DHAV-1, both received nanoemulsion throughout the experiment. Group 5 (G5, the therapeutic group), on the other hand, which was infected with DHAV-1 received nanoemulsion only from the onset of clinical signs. At 5 days old, the ducklings in the positive control (G2), the prophylactic (G4), and the therapeutic group (G5) were infected with DHAV-1. All the ducklings in the infected groups exhibited depression, anorexia, and opisthotonos, and their livers displayed various degrees of ecchymotic hemorrhage, liver enlargement, and microscopic pathological lesions. Notably, the positive control group (G2) experienced the most severe and pronounced effects compared to the other infected groups treated with the nanoemulsion. Meanwhile, the viral RNA loads were lower in the liver tissues of the infected ducklings treated with the nanoemulsion (G4, and G5) compared to the positive control group G2. Additionally, the nanoemulsion effectively modulated proinflammatory cytokine expression, antioxidant enzymes, liver enzymes, and lipid profile of treated ducklings. In conclusion, the turmeric and black pepper oil nanoemulsion has the potential to be a therapeutic agent for regulating and modulating the immune response, decreasing DHAV-1-induced cytokine storms, and minimizing mortality and economic losses in the duck business. More research is needed to understand how turmeric and black pepper oil nanoemulsion alleviates DHVA-1-induced cytokine storms and lowers duckling mortality. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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