Studying the photothermal activation of polydopamine-shelled, phase-change emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering.

Autor: Vidallon MLP; School of Chemistry, Monash University, Clayton, VIC 3800, Australia; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC 3010, Australia; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe Institute for Molecular Science University of Melbourne, Parkville VIC 3010, Australia. Electronic address: Mark.Vidallon@baker.edu.au., King JP; School of Chemistry, Monash University, Clayton, VIC 3800, Australia., Giles LW; School of Chemistry, Monash University, Clayton, VIC 3800, Australia., Crawford SA; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC 3800, Australia., Baldwin C; Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Rd, Lucas Heights, NSW 2234, Australia., Premilovac D; Tasmanian School of Medicine, University of Tasmania, 17 Liverpool Street, Hobart, TAS, 7000, Australia., Mian Teo B; School of Chemistry, Monash University, Clayton, VIC 3800, Australia., Bishop AI; School of Physics and Astronomy, Monash University, Clayton, VIC, 3800, Australia., de Campo L; Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Rd, Lucas Heights, NSW 2234, Australia. Electronic address: liliana.decampo@ansto.gov.au., Tabor RF; School of Chemistry, Monash University, Clayton, VIC 3800, Australia. Electronic address: Rico.Tabor@monash.edu.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2024 Apr; Vol. 659, pp. 1029-1041. Date of Electronic Publication: 2024 Jan 06.
DOI: 10.1016/j.jcis.2024.01.004
Abstrakt: Polydopamine-shelled perfluorocarbon (PDA/PFC) emulsion droplets are promising candidates for medical imaging and drug delivery applications. This study investigates their phase transition into microbubbles under near-infrared (NIR) illumination in situ using small- and ultra-small-angle neutron scattering (SANS and USANS) and contrast variation techniques. Supported by optical microscopy, thermogravimetric analysis, and ultrasound imaging, SANS and USANS results reveal rapid phase transition rates upon NIR illumination, dependent on PFC content and droplet size distribution. Specifically, perfluoropentane droplets rapidly transform into bubbles upon NIR irradiation, whereas perfluorohexane droplets exhibit greater resistance to phase change (bulk boiling points = 30 °C and 60 °C, respectively). Furthermore, smaller emulsion droplets with unimodal distribution resist NIR-triggered phase changes better than their bimodal counterparts. This observation is attributable to the lower boiling points of large emulsion droplets (lower Laplace pressure than smaller droplets) and the faster photothermal heating rates due to their thicker polydopamine shells. The insights gained from these techniques are crucial for designing phase-change emulsions activated by NIR for photothermal therapies and controlled drug delivery.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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