Time is the enemy: Negative symptoms are related to even slight differences in the duration of untreated psychosis.
Autor: | Slováková A; National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: andrea.slovakova@bohnice.cz., Kúdelka J; National Institute of Mental Health, Klecany, Czech Republic., Škoch A; National Institute of Mental Health, Klecany, Czech Republic; Institute for Clinical and Experimental Medicine, Department of Diagnostic and Interventional Radiology, Prague, Czech Republic. Electronic address: antonin.skoch@nudz.cz., Jakob L; National Institute of Mental Health, Klecany, Czech Republic. Electronic address: lea.jakob@nudz.cz., Fialová M; National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: marketa.fialova@nudz.cz., Fürstová P; National Institute of Mental Health, Klecany, Czech Republic. Electronic address: petra.furstova@nudz.cz., Bakštein E; National Institute of Mental Health, Klecany, Czech Republic. Electronic address: bakstedu@fel.cvut.cz., Bankovská Motlová L; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: lucie.bankovska@lf3.cuni.cz., Knytl P; National Institute of Mental Health, Klecany, Czech Republic. Electronic address: pavel.knytl@nudz.cz., Španiel F; National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: filip.spaniel@nudz.cz. |
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Jazyk: | angličtina |
Zdroj: | Comprehensive psychiatry [Compr Psychiatry] 2024 Apr; Vol. 130, pp. 152450. Date of Electronic Publication: 2024 Jan 14. |
DOI: | 10.1016/j.comppsych.2024.152450 |
Abstrakt: | Background: Negative symptoms (NS) represent a detrimental symptomatic domain in schizophrenia affecting social and occupational outcomes. Aims: We aimed to identify factors from the baseline visit (V1) - with a mean illness duration of 0.47 years (SD = 0.45) - that predict the magnitude of NS at the follow-up visit (V3), occurring 4.4 years later (mean +/- 0.45). Method: Using longitudinal data from 77 first-episode schizophrenia spectrum patients, we analysed eight predictors of NS severity at V3: (1) the age at disease onset, (2) age at V1, (3) sex, (4) diagnosis, (5) NS severity at V1, (6) the dose of antipsychotic medication at V3, (7) hospitalisation days before V1 and; (8) the duration of untreated psychosis /DUP/). Secondly, using a multiple linear regression model, we studied the longitudinal relationship between such identified predictors and NS severity at V3 using a multiple linear regression model. Results: DUP (Pearson's r = 0.37, p = 0.001) and NS severity at V1 (Pearson's r = 0.49, p < 0.001) survived correction for multiple comparisons. The logarithmic-like relationship between DUP and NS was responsible for the initial stunning incremental contribution of DUP to the severity of NS. For DUP < 6 months, with the sharpest DUP/NS correlation, prolonging DUP by five days resulted in a measurable one-point increase in the 6-item negative symptoms PANSS domain assessed 4.9 (+/- 0.6) years after the illness onset. Prolongation of DUP to 14.7 days doubled this NS gain, whereas 39 days longer DUP tripled NS increase. Conclusion: The results suggest the petrification of NS during the early stages of the schizophrenia spectrum and a crucial dependence of this symptom domain on DUP. These findings are clinically significant and highlight the need for primary preventive actions. Competing Interests: Declaration of competing interest The authors declare that they have no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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