A Case of Enterococcal Patent Ductus Arteriosus-associated Endarteritis in a Preterm Neonate.

Autor:	Mayer A; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico., Crippa BL; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico., Pietrasanta C; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.; Department of Clinical Sciences and Community Health, University of Milan., Picciolli I; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico., Ronchi A; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico., Raschetti R; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico., Bandera A; Medical Department, Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.; Department of Pathophysiology and Transplantation, University of Milan., Colli AM; Cardio-Thoraco-Vascular Department, Cardiology Unit, Paediatric Cardiology Service, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Mosca F; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.; Department of Clinical Sciences and Community Health, University of Milan., Francescato G; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico., Pugni L; From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
Jazyk:	angličtina
Zdroj:	The Pediatric infectious disease journal [Pediatr Infect Dis J] 2024 Apr 01; Vol. 43 (4), pp. 351-354. Date of Electronic Publication: 2024 Jan 18.
DOI:	10.1097/INF.0000000000004232
Abstrakt:	Introduction: The persistent patency of the ductus arteriosus frequently occurs in premature neonates and can cause infective endocarditis (IE) or ductal endarteritis (DE) during sepsis. Even though neonatal IE and DE are believed to be a rare eventuality, their incidence has been increasing in the last decades due to the improved survival of even more preterm babies, favored by highly invasive procedures and therapies. In parallel, antimicrobial resistance is another rising problem in neonatal intensive care units, which frequently compels to treat infections with broad-spectrum or last generation antibiotics. Case Presentation: We report the case of a preterm neonate affected by patent ductus arteriosus-associated DE that followed an episode of sepsis caused by a high-level aminoglycoside-resistant enterococcus. The neonate was successfully treated with the synergistic combination of ampicillin and cefotaxime. Discussion: IE and patent ductus arteriosus-associated DE are rising inside neonatal intensive care units and neonatologists should be aware of these conditions. Enterococcal IE and patent ductus arteriosus-associated DE sustained by high-level aminoglycoside-resistant strains can be successfully treated with the synergistic combination of ampicillin and cefotaxime even in preterm neonates. Competing Interests: The authors have no funding or conflicts of interest to disclose. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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