Plasma Copper and Metabolic Syndrome in Mesoamerican Children and Their Parents.

Autor: Villatoro-Santos CR; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, SPH II, Room M5507, Ann Arbor, MI, 48109, USA., Ramirez-Zea M; Institute of Nutrition of Central America and Panama, INCAP Research Center for the Prevention of Chronic Diseases, Guatemala City, Guatemala., Villamor E; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, SPH II, Room M5507, Ann Arbor, MI, 48109, USA. villamor@umich.edu.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Nov; Vol. 202 (11), pp. 4903-4908. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1007/s12011-024-04069-9
Abstrakt: The role of copper in the etiology of metabolic syndrome (MetS) is uncertain. We evaluated associations of plasma copper concentrations with MetS and its components in a cross-sectional study of 198 children ages 7-12 years and 378 adult parents from eight Mesoamerican countries. In children, the outcome was a metabolic risk score based on waist circumference, insulin resistance, mean arterial pressure (MAP), and blood lipids. In adults, we defined MetS per Adult Treatment Panel III criteria. Plasma copper was not significantly related to MetS in children or adults; however, children with copper above the median had a MAP score 0.04 (95% CI, 0.002, 0.08; P = 0.04) adjusted units higher and a HDL-cholesterol score 0.07 (95% CI, - 0.13, - 0.003; P = 0.04) adjusted units lower than those with lower copper concentrations. In adults, copper was positively related to abdominal obesity. Longitudinal studies to confirm the deleterious role of copper on MetS components are warranted.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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