One-Dimensional HKUST-1-Decorated Glassy Carbon Electrode for the Sensitive Electrochemical Immunosensor of NS1 Dengue Virus Serotype-3.

Autor:	Dewi KK; Advanced Functional Materials Laboratory, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia.; BRIN and ITB Collaboration Research Center for Biosensor and Biodevices, Institut Teknologi Bandung, Bandung40132, Indonesia., Septiani NLW; Advanced Functional Materials Laboratory, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia.; Research Center for Advanced Materials, National Research and Innovation Agency (BRIN), South Tangerang, Banten 15314, Indonesia.; BRIN and ITB Collaboration Research Center for Biosensor and Biodevices, Institut Teknologi Bandung, Bandung40132, Indonesia., Wustoni S; Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal23955-6900, Saudi Arabia., Nugraha; Advanced Functional Materials Laboratory, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia.; Research Center for Nanoscience and Nanotechnology (RCNN), Institut Teknologi Bandung, Bandung40132, Indonesia., Jenie SNA; BRIN and ITB Collaboration Research Center for Biosensor and Biodevices, Institut Teknologi Bandung, Bandung40132, Indonesia.; Research Center for Chemistry, National Research and Innovation Agency (BRIN), Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Banten 15314, Indonesia., Manurung RV; BRIN and ITB Collaboration Research Center for Biosensor and Biodevices, Institut Teknologi Bandung, Bandung40132, Indonesia.; Research Centre for Electronics, National Research and Innovation Agency (BRIN), Komplek LIPI Gd. 20, Bandung, Jawa Barat 40135, Indonesia., Yuliarto B; Advanced Functional Materials Laboratory, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia.; BRIN and ITB Collaboration Research Center for Biosensor and Biodevices, Institut Teknologi Bandung, Bandung40132, Indonesia.; Research Center for Nanoscience and Nanotechnology (RCNN), Institut Teknologi Bandung, Bandung40132, Indonesia.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2023 Dec 21; Vol. 9 (1), pp. 1454-1462. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).
DOI:	10.1021/acsomega.3c07856
Abstrakt:	In this work, simple and sensitive detection of dengue virus serotype-3 (DENV-3) antigen was accomplished by a one-dimensional (1D) HKUST-1-functionalized electrochemical sensor. 1D HKUST-1 was synthesized via a coprecipitation method using triethanolamine (TEOA) as pH modulator and structure-directing agent. The structure, morphology, and sensing performance of the HKUST-1-decorated carbon electrode were characterized by X-ray diffraction (XRD), infrared spectroscopy (FTIR), scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). We found that 40 wt% TEOA transforms the octahedron HKUST-1 to the nanorods while maintaining its crystal structure and providing chemical stability. The 1D HKUST-1-decorated carbon electrode successfully detects the antigen in the range of 0.001-10 ng/mL with a detection limit of 0.932 pg/mL. The immunosensor also exhibits remarkable performance in analyzing the antigen in human serum and showed recovery as high as ∼98% with excellent selectivity and reproducibility. Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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