| Autor: |
Wang L; Department of Intensive Care Medicine, Hangzhou Normal University Affiliated Hospital, Hangzhou 310015, China., Qu HJ; Department of Endocrinology, Hangzhou Normal University Affiliated Hospital, Hangzhou 310015, China., Yang WJ; Department of Pathology, Hangzhou Normal University Affiliated Hospital, Hangzhou 310015, China., Ding JP; Department of Radiology, Hangzhou Normal University Affiliated Hospital, Hangzhou 310015, China., Shi JP; Department of Hepatology, Hangzhou Normal University Affiliated Hospital, Hangzhou 310015, China., Zhang QL; Department of Endocrinology, Hangzhou Normal University Affiliated Hospital, Hangzhou 310015, China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology [Zhonghua Gan Zang Bing Za Zhi] 2023 Nov 20; Vol. 31 (11), pp. 1204-1208. |
| DOI: |
10.3760/cma.j.cn501113-20230902-00086 |
| Abstrakt: |
Objective: To explore the relationship between liver iron deposition and steatosis in patients with non-alcoholic fatty liver disease (NAFLD) through MRI. Methods: 163 cases of liver biopsy underwent MRI examination. R2* was used to measure liver iron content. Dixon-based proton density fat fraction (PDFF) was used to measure liver fat content. One-way ANOVA, r-correlation, ROC curve, and others were used to assess the relationship between clinical case data, serological indices, and imaging results in accordance with the pathological results of the liver biopsy. Results: R2* gradually increased as the pathological steatosis grade rose. The R2* that corresponded to no steatosis (< 5%), mild steatosis (14.95%±8.55%), moderate steatosis (46.30%±9.32%), and severe steatosis (73.86%±6.35%) were 27.56±4.40, 31.06±5.95, 38.06±4.80, and 48.10±5.55 ( P < 0.001), respectively. There was a positive correlation between R2* and liver steatosis content ( r = 0.769, P < 0.05). The area under the ROC curve and cut-off value were 0.88 and 31.77, respectively, and there was no distinct relationship with liver inflammation or fibrosis. Conclusion: R2* can quantitatively and non-invasively evaluate liver iron deposition in patients with NAFLD. A distinct relationship exists between liver steatosis and iron deposition, and iron deposition tends to increase as the steatosis aggravates. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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