CuO nanoparticles for green synthesis of significant anti-Helicobacter pylori compounds with in silico studies.

Autor: Shehab WS; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt. dr.wesamshehab@gmail.com., Elsayed DA; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt. doaaatef641995@gmail.com., Abdel Hamid AM; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Assy MG; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Mouneir SM; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Cairo, 12211, Egypt., Hamed EO; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Mousa SM; Inorganic Chemistry Department, National Research Centre, 33 El-Buhouth St., Dokki, Cairo, 12622, Egypt., El-Bassyouni GT; Ceramics and Building Materials Department, National Research Centre, 33 El-Buhouth St., Dokki, Cairo, 12622, Egypt.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jan 18; Vol. 14 (1), pp. 1608. Date of Electronic Publication: 2024 Jan 18.
DOI: 10.1038/s41598-024-51708-1
Abstrakt: Helicobacter pylori (H. pylori) is a universal health intimidation as mentioned by the World Health Organization. The primary causal agent linked to a number of illnesses, including inflammation and the development of stomach ulcers, is Helicobacter pylori. Since, H. pylori develops antibiotic resistance quickly, current H. pylori treatment approaches are becoming less effective. Our research aims to highlight novel formulation antibiotics using CuO-NPs as catalysts and studied their activity as anti-helicobacter pylori supported by computational studies (POM analysis and molecular docking) software. They were designed for anti-Helicobacter Pylori action. All compounds revealed a bactericidal effect better than the reference McFarland standards.
(© 2024. The Author(s).)
Databáze: MEDLINE
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