Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory proteome.

Autor: Schnorr I; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Siegl A; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Luckhardt S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany., Wenz S; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Friedrichsen H; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., El Jomaa H; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Steinmann A; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Kilencz T; Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary., Arteaga-Henríquez G; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain.; Biomedical Network Research Center on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain.; NCRR-The National Center for Register-Based Research, Aarhus University, Aarhus, Denmark., Ramos-Sayalero C; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain., Ibanez-Jimenez P; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain., Rosales-Ortiz SK; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain., Bitter I; Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary., Fadeuilhe C; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain.; Biomedical Network Research Center on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain., Ferrer M; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain.; Biomedical Network Research Center on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autónoma de Barcelona, Barcelona, Catalonia, Spain., Lavebratt C; Department of Molecular Medicine and Surgery, Karolinska Institutet, and Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Réthelyi JM; Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary., Richarte V; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain.; Biomedical Network Research Center on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain.; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands., Rommelse N; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary., Ramos-Quiroga JA; Department of Mental Health, Hospital Universitari Vall d´Hebron, Barcelona, Catalonia, Spain.; Biomedical Network Research Center on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain., Arias-Vasquez A; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.; Department of Psychiatry, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands., Resch E; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany., Reif A; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany., Matura S; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Schiweck C; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany. schiweck@med.uni-frankfurt.de.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 Jan 18; Vol. 14 (1), pp. 37. Date of Electronic Publication: 2024 Jan 18.
DOI: 10.1038/s41398-023-02729-3
Abstrakt: The association between Attention Deficit Hyperactivity Disorder (ADHD) and low-grade inflammation has been explored in children but rarely in adults. Inflammation is characteristic of some, but not all, patients with ADHD and might be influenced by ADHD medication but also lifestyle factors including nutrition, smoking, and stress. It is also still unclear if any specific symptoms are related to inflammation. Therefore, we assessed 96 inflammatory proteins in a deeply phenotyped cohort of 126 adult ADHD participants with a stable medication status using OLINK technology. A data-based, unsupervised hierarchical clustering method could identify two distinct biotypes within the 126 ADHD participants based on their inflammatory profile: a higher inflammatory potential (HIP) and a lower inflammatory protein potential (LIP) group. Biological processes that differed strongest between groups were related to the NF-κB pathway, chemokine signaling, IL-17 signaling, metabolic alterations, and chemokine attraction. A comparison of sample characteristics revealed that the HIP group was more likely to have higher levels of chronic stress (p < 0.001), a higher clinical global impression scale score (p = 0.030), and a higher risk for suicide (p = 0.032). Medication status did not influence protein levels significantly (p ≥ 0.074), but psychotropic co-medication (p ≤ 0.009) did. In conclusion, our data suggest the presence of two distinct biotypes in adults with ADHD. Higher levels of inflammatory proteins in ADHD are linked to higher levels of chronic perceived stress in a linear fashion. Further research on inflammation in adults with ADHD should take stress levels into account.
(© 2024. The Author(s).)
Databáze: MEDLINE
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