Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome.

Autor:	NaveenKumar SK; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Tambralli A; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.; Division of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, MI., Fonseca BM; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.; Hematology and Hemotherapy Center, Department of Pathology, University of Campinas, Campinas, Brazil., Yalavarthi S; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Liang W; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Hoy CK; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Sarosh C; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Rysenga CE; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Ranger CH; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Vance CE; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Madison JA; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.; Division of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, MI., Orsi FA; Hematology and Hemotherapy Center, Department of Pathology, University of Campinas, Campinas, Brazil., Sood SL; Division of Hematology & Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Schaefer JK; Division of Hematology & Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Zuo Y; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI., Knight JS; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Jazyk:	angličtina
Zdroj:	Blood [Blood] 2024 Mar 21; Vol. 143 (12), pp. 1193-1197.
DOI:	10.1182/blood.2023022097
Abstrakt:	Abstract: Many patients with antiphospholipid syndrome had decreased ectonucleotidase activity on neutrophils and platelets, which enabled extracellular nucleotides to trigger neutrophil-platelet aggregates. This phenotype was replicated by treating healthy neutrophils and platelets with patient-derived antiphospholipid antibodies or ectonucleotidase inhibitors. (© 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.)
Databáze:	MEDLINE
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