Partial-Volume Irradiation of Murine Tumors.

Autor:	Modic Z; Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Markelc B; Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia., Jesenko T; Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia. tjesenko@onko-i.si.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. tjesenko@onko-i.si.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2773, pp. 97-104.
DOI:	10.1007/978-1-0716-3714-2_10
Abstrakt:	Radiotherapy is a widely used approach for cancer treatment. However, delivering a single high dose of radiation to bulky tumors can be challenging due to the toxicities induced in the surrounding healthy tissue. To overcome this issue, a nonuniform high dose can be delivered using partial-volume tumor irradiation or spatially fractionated radiotherapy (SFRT). Moreover, SFRT has the potential to induce a stronger antitumor immune response compared to traditional radiotherapy due to the preservation of immune cells in the unirradiated tumor regions. There are several SFRT approaches, including GRID therapy, three-dimensional GRID therapy (LATTICE), microbeam radiation therapy (MRT), and Stereotactic Body Radiation Therapy for PArtial Tumor irradiation targeting exclusively the HYpoxic segment (SBRT-PATHY). The following protocol describes partial-volume tumor irradiation, a technique that enables dose delivery to only a part of the tumor in mice using an X-ray generator and collimators of different dimensions that limit the size of the irradiation field. (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
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