Preclinical Mouse Metastatic Model Established Through Induced Lung Metastases.

Autor:	Uršič Valentinuzzi K; Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.; Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia., Serša G; Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.; Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia., Kamenšek U; Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia. Ukamensek@onko-i.si.; Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia. Ukamensek@onko-i.si.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2773, pp. 77-86.
DOI:	10.1007/978-1-0716-3714-2_8
Abstrakt:	Metastatic disease is the major cause of cancer death, and the lung is one of the most common sites of cancer metastases. To investigate systemic antitumor effects or protective potential of local therapies, mouse models with induced metastases are indispensable in preclinical cancer research. Here, we describe the protocol for the metastatic mouse model established through induced 4T1 mammary carcinoma metastases. With minor prior optimization, it can be applied to other tumor cell lines of interest. (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
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