Genetically modified mice as a tool for the study of human diseases.

Autor: Bruter AV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia, 119334.; Federal State Budgetary Institution 'National Medical Research Center of Oncology Named After N.N. Blokhin' of the Ministry of Health of the Russian Federation, Research Institute of Carcinogenesis, Moscow, Russia, 115478., Varlamova EA; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia, 119334.; Federal State Budgetary Institution 'National Medical Research Center of Oncology Named After N.N. Blokhin' of the Ministry of Health of the Russian Federation, Research Institute of Carcinogenesis, Moscow, Russia, 115478., Okulova YD; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia, 119334., Tatarskiy VV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia, 119334., Silaeva YY; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia, 119334., Filatov MA; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia, 119334. maxfilat@yandex.ru.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Jan 18; Vol. 51 (1), pp. 135. Date of Electronic Publication: 2024 Jan 18.
DOI: 10.1007/s11033-023-09066-0
Abstrakt: Modeling a human disease is an essential part of biomedical research. The recent advances in the field of molecular genetics made it possible to obtain genetically modified animals for the study of various diseases. Not only monogenic disorders but also chromosomal and multifactorial disorders can be mimicked in lab animals due to genetic modification. Even human infectious diseases can be studied in genetically modified animals. An animal model of a disease enables the tracking of its pathogenesis and, more importantly, to test new therapies. In the first part of this paper, we review the most common DNA modification technologies and provide key ideas on specific technology choices according to the task at hand. In the second part, we focus on the application of genetically modified mice in studying human diseases.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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