Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY).

Autor:	Olsson A; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Bouaoun L; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Schüz J; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Vermeulen R; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Behrens T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum, Germany., Ge C; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Kromhout H; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Siemiatycki J; Department of Social and Preventive Medicine, University of Montreal, Montreal, Canada., Gustavsson P; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Boffetta P; Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Kendzia B; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum, Germany., Radoi L; Center for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, U1018 Inserm, University Paris-Saclay, University Paris Cité, Villejuif, France., Barul C; University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) -UMR_S 1085, Pointe-à-Pitre, France., Karrasch S; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.; Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Wichmann HE; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institut für Medizinische Informatik Biometrie Epidemiologie, Ludwig Maximilians University, Munich, Germany., Consonni D; Epidemiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Landi MT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA., Caporaso NE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA., Merletti F; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Migliore E; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Richiardi L; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany., Ahrens W; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.; Faculty of Mathematics and Computer Science, Institute of Statistics, University of Bremen, Bremen, Germany., Pohlabeln H; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany., Fernández-Tardón G; Health Research Institute of Asturias, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain., Zaridze D; Department of Cancer Epidemiology and Prevention, N.N. Blokhin National Research Centre of Oncology, Moscow, Russia., Field JK; Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Lissowska J; Epidemiology Unit, Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Świątkowska B; Department of Environmental Epidemiology, The Nofer Institute of Occupational Medicine, Lodz, Poland., McLaughlin JR; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Demers PA; Occupational Cancer Research Centre, Ontario Health, Toronto, Canada., Schejbalova M; Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Prague, Czech Republic., Foretova L; Masaryk Memorial Cancer Institute, Brno, Czech Republic., Janout V; Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic., Pándics T; National Public Health Center, Budapest, Hungary., Fabianova E; Regional Authority of Public Health, Banská Bystrica, Slovakia.; Faculty of Health, Catholic University, Ružomberok, Slovakia., Mates D; National Institute of Public Health, Bucharest, Romania., Forastiere F; Department of Epidemiology, ASL Roma E, Rome, Italy., Straif K; ISGlobal, Barcelona, Spain.; Boston College, Chestnut Hill, Massachusetts, USA., Brüning T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum, Germany., Vlaanderen J; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Peters S; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Jazyk:	angličtina
Zdroj:	Environmental health perspectives [Environ Health Perspect] 2024 Jan; Vol. 132 (1), pp. 17005. Date of Electronic Publication: 2024 Jan 18.
DOI:	10.1289/EHP13380
Abstrakt:	Background: While much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents. Objectives: We investigated the pairwise joint effects of occupational exposures to asbestos, respirable crystalline silica, metals (i.e., nickel, chromium-VI), and polycyclic aromatic hydrocarbons (PAH) on lung cancer risk, overall and by major histologic subtype, while accounting for cigarette smoking. Methods: In the international 14-center SYNERGY project, occupational exposures were assigned to 16,901 lung cancer cases and 20,965 control subjects using a quantitative job-exposure matrix (SYN-JEM). Odds ratios (ORs) and 95% confidence intervals (CIs) were computed for ever vs. never exposure using logistic regression models stratified by sex and adjusted for study center, age, and smoking habits. Joint effects among pairs of agents were assessed on multiplicative and additive scales, the latter by calculating the relative excess risk due to interaction (RERI). Results: All pairwise joint effects of lung carcinogens in men were associated with an increased risk of lung cancer. However, asbestos/metals and metals/PAH resulted in less than additive effects; while the chromium-VI/silica pair showed marginally synergistic effect in relation to adenocarcinoma (RERI: 0.24; CI: 0.02, 0.46; p = 0.05). In women, several pairwise joint effects were observed for small cell lung cancer including exposure to PAH/silica (OR = 5.12; CI: 1.77, 8.48), and to asbestos/silica (OR = 4.32; CI: 1.35, 7.29), where exposure to PAH/silica resulted in a synergistic effect (RERI: 3.45; CI: 0.10, 6.8). Discussion: Small or no deviation from additive or multiplicative effects was observed, but co-exposure to the selected lung carcinogens resulted generally in higher risk than exposure to individual agents, highlighting the importance to reduce and control exposure to carcinogens in workplaces and the general environment. https://doi.org/10.1289/EHP13380.
Databáze:	MEDLINE
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