Preparation of new organo-ruthenium(II) complexes and their nucleic acid/albumin binding efficiency and in vitro cytotoxicity studies.

Autor:	Sindhu M; Department of Chemistry, Nirmala College for Women, Bharathiar University, Coimbatore 641 018, India. kalaivani19@gmail.com., Kalaivani P; Department of Chemistry, Nirmala College for Women, Bharathiar University, Coimbatore 641 018, India. kalaivani19@gmail.com., Prabusankar G; Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi 502 285, India., Sivasamy R; Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, India., Prabhakaran R; Department of Chemistry, Bharathiar University, Coimbatore 641 046, India. rpnchemist@gmail.com.
Jazyk:	angličtina
Zdroj:	Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2024 Feb 13; Vol. 53 (7), pp. 3075-3096. Date of Electronic Publication: 2024 Feb 13.
DOI:	10.1039/d3dt04017h
Abstrakt:	Hetero-bimetallic ruthenium(II) complexes (PRAFIZ and PRBFIZ) containing acetyl ferrocene (AFIZ)/benzoyl ferrocene isonicotinic hydrazone ligands (BFIZ) were synthesized and characterized by various spectral and analytical techniques. The structure of acetyl ferrocene isonicotinic hydrazone (AFIZ) and the complex PRBFIZ was confirmed by X-ray crystallography. The hydrazide ligands coordinated in a bidentate monobasic fashion using their N1 hydrazinic nitrogen and enolic oxygen atoms. The binding interactions of the ligands and complexes were examined using Calf-Thymus DNA (CT-DNA) and bovine serum albumin (BSA). Scanning Electron Microscopic (SEM) experiments clarified the efficient binding interaction of the ligands and complexes with BSA. The results of in vitro cytotoxicity studies on MDA-MB-261 breast cancer cells and A549 human lung cancer cells and cell morphological analysis results through staining assays clearly indicated the cytotoxic nature of the complexes.
Databáze:	MEDLINE
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