Computational models of bone fracture healing and applications: a review.
| Autor: | Wang M; School of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbin, Heilongjiang, China., Jiang G; School of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbin, Heilongjiang, China., Yang H; School of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbin, Heilongjiang, China., Jin X; School of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbin, Heilongjiang, China. |
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| Jazyk: | angličtina |
| Zdroj: | Biomedizinische Technik. Biomedical engineering [Biomed Tech (Berl)] 2024 Jan 19; Vol. 69 (3), pp. 219-239. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024). |
| DOI: | 10.1515/bmt-2023-0088 |
| Abstrakt: | Fracture healing is a very complex physiological process involving multiple events at different temporal and spatial scales, such as cell migration and tissue differentiation, in which mechanical stimuli and biochemical factors assume key roles. With the continuous improvement of computer technology in recent years, computer models have provided excellent solutions for studying the complex process of bone healing. These models not only provide profound insights into the mechanisms of fracture healing, but also have important implications for clinical treatment strategies. In this review, we first provide an overview of research in the field of computational models of fracture healing based on CiteSpace software, followed by a summary of recent advances, and a discussion of the limitations of these models and future directions for improvement. Finally, we provide a systematic summary of the application of computational models of fracture healing in three areas: bone tissue engineering, fixator optimization and clinical treatment strategies. The application of computational models of bone healing in clinical treatment is immature, but an inevitable trend, and as these models become more refined, their role in guiding clinical treatment will become more prominent. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.) |
| Databáze: | MEDLINE |
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