| Autor: |
Serra ND; Dept. of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA., Darwin CB; Dept. of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA., Sundaram MV; Dept. of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA. |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 26. Date of Electronic Publication: 2023 Dec 26. |
| DOI: |
10.1101/2023.12.26.573316 |
| Abstrakt: |
In C. elegans , divergent Hedgehog-related (Hh-r) and Patched-related (PTR) proteins promote numerous processes ranging from epithelial and sense organ development to pathogen responses to cuticle shedding during the molt cycle. Here we show that Hh-r proteins are actual components of the cuticle and pre-cuticle apical extracellular matrices (aECMs) that coat, shape, and protect external epithelia. Different Hh-r proteins stably associate with the aECMs of specific tissues and with specific substructures such as furrows and alae. Hh-r mutations can disrupt matrix structure. These results provide a unifying model for the function of nematode Hh-r proteins and highlight ancient connections between Hh proteins and the extracellular matrix. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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